Issue 4, 2006
From the journal:

Soft Matter

Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics

David M. Lynn*a  

* Corresponding authors

a Department of Chemical and Biological Engineering, University of Wisconsin – Madison, 1415 Engineering Drive, Madison, WI, 53706, USA
E-mail: dlynn@engr.wisc.edu

Abstract

Layer-by-layer approaches to the fabrication of nanostructured polymer assemblies have contributed to the design of thin films and composites of interest in a variety of areas. Here, we highlight recent contributions from our laboratory toward the design of multilayered assemblies that erode controllably and predictably in physiological environments and permit spatial and temporal control over the administration of macromolecular therapeutics, such as DNA. Our approach makes use of assemblies fabricated from hydrolytically degradable polyamines. We place this work in the context of recent progress from other laboratories and discuss new opportunities and connections that illustrate the potential of these layered assemblies as platforms for the controlled release of one or several therapeutic agents.

Graphical abstract: Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics

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Article information

DOI
https://doi.org/10.1039/B517860F
Article type
Highlight
Submitted
15 Dec 2005
Accepted
24 Jan 2006
First published
10 Feb 2006

Soft Matter, 2006,2, 269-273

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Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics

D. M. Lynn, Soft Matter, 2006, 2, 269 DOI: 10.1039/B517860F

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