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Soft Matter

Where physics meets chemistry meets biology for fundamental soft matter research.



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Soft Matter, 2007, 3, 290 - 298, DOI: 10.1039/b607615g

Microcontact printing of proteins for neuronal cell guidance

Andreas Offenhäusser, Simone Böcker-Meffert, Tanja Decker, Rita Helpenstein, Peter Gasteier, Jürgen Groll, Martin Möller, Anna Reska, Susanne Schäfer, Petra Schulte and Angela Vogt-Eisele

The growth of neurons into networks of controlled geometry is of great interest in the field of cell-based biosensors, neuroelectronic circuits, neurological implants, pharmaceutical testing as well as fundamental biological questions about neuronal interactions. The precise control of the network architecture can be achieved by defined engineering of the surface material properties: this process is called neuronal cell patterning. Different techniques can be used to produce such surface patterns. We have chosen microcontact printing (µCP), because it is a comparatively simple and universal method for patterning biomolecules.

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