Issue 11, 2007
From the journal:

Soft Matter

Responsive viscoelastic giant lipid vesicles filled with a poly(N-isopropylacrylamide) artificial cytoskeleton

Clément Campillo,†a   Brigitte Pépin-Donatb  and  Annie Viallat*a  

* Corresponding authors

a Adhésion et Inflammation, Inserm U600, CNRS UMR 62 12 Université Méditerranée, case 937, 163 av de Luminy, 13288 Marseille Cedex, France
E-mail: viallat@marseille.inserm.fr
Fax: +33 491 828 851
Tel: +33 491 828 853

b Laboratoire d'Electronique Moléculaire et Hybride, UMR 5819 SPrAM (CEA-CNRS-UJF)/DRFMC/CEA-Grenoble, 38054 Grenoble Cedex 9, France
E-mail: brigitte.pepin-donat@cea.fr
Tel: +33 438 783 806

Abstract

Responsive giant lipid vesicles filled with aqueous PolyNipam sol (SFV) or gel (GFV) were prepared by ultra-violet polymerisation performed in situ. Upon crossing the lower critical transition temperature of PolyNipam, SFVs and GFVs undergo a significant change of their structural and mechanical properties or a drastic volume transition, respectively. Rheometric and micropipette experiments show that both internal viscosity of SFVs and internal shear modulus of GFVs are tunable over several orders of magnitude and lie in the range observed for living cells. Moreover, the vesicle membrane is strongly bound to the internal polymer medium, making these systems interesting for mimicking the basic mechanical behaviour of passive living cells.

Graphical abstract: Responsive viscoelastic giant lipid vesicles filled with a poly(N-isopropylacrylamide) artificial cytoskeleton

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Article information

DOI
https://doi.org/10.1039/B710474J
Article type
Paper
Submitted
10 Jul 2007
Accepted
14 Aug 2007
First published
13 Sep 2007

Soft Matter, 2007,3, 1421-1427

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Responsive viscoelastic giant lipid vesicles filled with a poly(N-isopropylacrylamide) artificial cytoskeleton

C. Campillo, B. Pépin-Donat and A. Viallat, Soft Matter, 2007, 3, 1421 DOI: 10.1039/B710474J

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