Chemical biology news from across RSC Publishing.
Electricity generates implant coating with potential
22 May 2009
Researchers in Canada have found that a way to make medical implants last longer makes them more biocompatible than at first thought.
Stainless steel is often used in, for example, joint replacements, because it is cheap and corrosion resistant. Nevertheless its implants are not as long-lived in the body as those made of other materials, such as titanium or titanium alloys, so researchers have looked at modifying implant surfaces to make them more biocompatible.
SEM image of MC3T3 preosteoblasts on a CPP-modified SS316LS surface after two days of incubation
Previously, Sasha Omanovic and coworkers at McGill University, Montreal, have shown that electrically modifying the surface of stainless steel implants can increase their lifespan. Using a form of cyclic voltammetry known as cyclic potentiodynamic passivation (CPP) the researchers can produce a film layer on the surface of stainless steel which is resistant to corrosion under physiological conditions. In their latest work, they have found the technique has further advantages. Omanovic explains that 'CPP influences the surface concentration and structure of the cell-binding protein fibronectin which leads to a healthier morphology of bone-forming cells.'
- Sasha Omanovic
Omanovic points out that fundamental challenges remain to be tackled. 'The origin of the improved protein-cell-surface interactions we report is not completely understood,' he says. 'This requires further studies, especially on the influence of the surface properties, such as charge, wettability, and topography, on fibronectin's conformation, and how this influences the interactions of various cells with the surface.'
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Link to journal article
The positive influence of electrochemical cyclic potentiodynamic passivation (CPP) of a SS316LS surface on its response to fibronectin and pre-osteoblasts
Arash Shahryari, Fereshteh Azari, Hojatollah Vali and Sasha Omanovic, Phys. Chem. Chem. Phys., 2009, 11, 6218
Also of interest
Thanks to nanotechnology, today's bone implants are so much more than your grandparent's hip replacement, say Thomas Webster and colleagues at Brown University, US
Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function
Maxime D. Guillemette, Bo Cui, Emmanuel Roy, Robert Gauvin, Claude J. Giasson, Mandy B. Esch, Patrick Carrier, Alexandre Deschambeault, Michel Dumoulin, Mehmet Toner, Lucie Germain, Teodor Veres and Francois A. Auger, Integr. Biol., 2009, 1, 196
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