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Highlights in Chemical Biology

Chemical biology news from across RSC Publishing.

Contents list for Highlights in Chemical Biology: Research Articles, issue 19, 2004

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Review Articles

Evaluation of different mechanistic proposals for water oxidation in photosynthesis on the basis of Mn4OxCa structures for the catalytic site and spectroscopic data
Johannes Messinger,  Phys. Chem. Chem. Phys., 2004, 6, 4764
DOI: 10.1039/b406437b

Consequences of structural and biophysical studies for the molecular mechanism of photosynthetic oxygen evolution: functional roles for calcium and bicarbonate
Jyotishman Dasgupta, Rogier T. van Willigen and G. Charles Dismukes,  Phys. Chem. Chem. Phys., 2004, 6, 4793
DOI: 10.1039/b408270b


Mechanistic analogies amongst carbohydrate modifying enzymes
Luke L. Lairson and Stephen G. Withers,  Chem. Commun., 2004, 2243
DOI: 10.1039/b406490a


Quantum chemical studies of dioxygen activation by mononuclear non-heme iron enzymes with the 2-His-1-carboxylate facial triad
Arianna Bassan, Tomasz Borowski and Per E. M. Siegbahn,  Dalton Trans., 2004, 3153
DOI: 10.1039/B408340G

Tutorial Reviews

Synchrotron and neutron techniques in biological crystallography
M. P. Blakeley, M. Cianci, J. R. Helliwell and P. J. Rizkallah,  Chem. Soc. Rev., 2004, 33, 548
DOI: 10.1039/b312779f

High-throughput protein crystallography and drug discovery
Ian Tickle, Andrew Sharff, Mladen Vinkovi, Jeff Yon and Harren Jhoti,  Chem. Soc. Rev., 2004, 33, 558
DOI: 10.1039/b314510g


Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis
Russell J. Cox, Frank Glod, Deirdre Hurley, Colin M. Lazarus, Thomas. P. Nicholson, Brian A. M. Rudd, Thomas J. Simpson, Barrie Wilkinson and Ying Zhang,  Chem. Commun., 2004, 2260
DOI: 10.1039/b411973h

Ultrastable complexes for in vivo use: a bifunctional chelator incorporating a cross-bridged macrocycle
Elizabeth A. Lewis, Ross W. Boyle and Stephen J. Archibald,  Chem. Commun., 2004, 2212
DOI: 10.1039/b406906d

Penicillins as -lactamase-dependent prodrugs: enabling role of a vinyl ester exocyclic to the lactam ring
Carol C. Ruddle and Timothy P. Smyth,  Chem. Commun., 2004, 2332
DOI: 10.1039/b409517k

Conformationally controlled high-affinity targeting of RNA or DNA by novel 2-amino-DNA/LNA mixmers and pyrenyl-functionalized 2-amino-DNA
Neerja Kalra, B. Ravindra Babu, Virinder S. Parmar and Jesper Wengel,  Org. Biomol. Chem., 2004, 2, 2885
DOI: 10.1039/B411626G


Mechanism and structure–reactivity relationships for aromatic hydroxylation by cytochrome P450
Christine M. Bathelt, Lars Ridder, Adrian J. Mulholland and Jeremy N. Harvey,  Org. Biomol. Chem., 2004, 2, 2998
DOI: 10.1039/B410729B

Synthesis of anti-tumour phosphatidylinositol analogues from glucose by the use of ring-closing olefin metathesis
Thomas L. Andresen, Dorthe M. Skytte and Robert Madsen,  Org. Biomol. Chem., 2004, 2, 2951
DOI: 10.1039/B411021H

On the role of the CP47 core antenna in the energy transfer and trapping dynamics of Photosystem II
Elena G. Andrizhiyevskaya, Dmitrij Frolov, Rienk van Grondelle and Jan P. Dekker,  Phys. Chem. Chem. Phys., 2004, 6, 4810
DOI: 10.1039/b411977k

Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform
Sylvain Ladame, James A. Schouten, John Stuart, Jose Roldan, Stephen Neidle and Shankar Balasubramanian,  Org. Biomol. Chem., 2004, 2, 2925
DOI: 10.1039/B409698C

Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids
Ferenc Zsila, Zsolt Bikádi and Miklós Simonyi,  Org. Biomol. Chem., 2004, 2, 2902
DOI: 10.1039/B409724F

Synthetic 6-aryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates for C–C hydrolase BphD: investigation of a general base catalytic mechanism
Damian M. Speare, Sarah M. Fleming, Martin N. Beckett, Jian-Jun Li and Timothy D. H. Bugg,  Org. Biomol. Chem., 2004, 2, 2942
DOI: 10.1039/B410322J

Structure-based mechanism of photosynthetic water oxidation
James P. McEvoy and Gary W. Brudvig,  Phys. Chem. Chem. Phys., 2004, 6, 4754
DOI: 10.1039/b407500e

Solvent affects the conformation of virginiamycin M1(pristinamycin IIA, streptogramin A)
Jason Dang, Mikael Bergdahl, Frances Separovic, Robert T. C. Brownlee and Robert P. Metzger,  Org. Biomol. Chem., 2004, 2, 2919
DOI: 10.1039/B407724E

Continuous cell washing and mixing driven by an ultrasound standing wave within a microfluidic channel
Jeremy J. Hawkes, Robert W. Barber, David R. Emerson and W. Terence Coakley,  Lab Chip, 2004, 4, 446
DOI: 10.1039/b408045a

Crystallization-induced dynamic resolution and analysis of the non-covalent interactions in the crystal packing of peptide–biphenyl hybrids
Bernardo Herradón, Ana Montero, Enrique Mann and Miguel A. Maestro,  CrystEngComm, 2004, 6, 513
DOI: 10.1039/b406652a

Radiopaque polymeric spinal cages: a prototype study
Catharina S. J. van Hooy-Corstjens, Yvette B. J. Aldenhoff, Menno L. W. Knetsch, Leon E. Govaert, Ece Arin, Hans Erli and Leo H. Koole,  J. Mater. Chem., 2004, 14, 3008
DOI: 10.1039/b407228f

Relaxation behaviour of the tyrosine YD radical in photosystem II: evidence for strong dipolar interaction with paramagnetic centers in the S1 and S2 states
Fikret Mamedov, Paul J. Smith, Stenbjörn Styring and Ron J. Pace,  Phys. Chem. Chem. Phys., 2004, 6, 4890
DOI: 10.1039/b407329k

Sequential DNA hybridisation assays by fast micromixing
Martin Heule and Andreas Manz,  Lab Chip, 2004, 4, 506
DOI: 10.1039/b404633a

Microcanals for micropipette access to single cells in microfluidic environments
Chia-Hsien Hsu, Chihchen Chen and Albert Folch,  Lab Chip, 2004, 4, 420
DOI: 10.1039/b404956j

Oxidation potentials and electron donation to photosystem II of manganese complexes containing bicarbonate and carboxylate ligands
Yuri N. Kozlov, Serguei K. Zharmukhamedov, Konstantin G. Tikhonov, Jyotishman Dasgupta, Alevtina A. Kazakova, G. Charles Dismukes and Vyacheslav V. Klimov,  Phys. Chem. Chem. Phys., 2004, 6, 4905
DOI: 10.1039/b406569g

Microfluidic biosensing systems
Part I. Development and optimisation of enzymatic chemiluminescent µ-biosensors based on silicon microchips

Richard Davidsson, Frédéric Genin, Martin Bengtsson, Thomas Laurell and Jenny Emnéus,  Lab Chip, 2004, 4, 481
DOI: 10.1039/b400894d

Microfluidic biosensing systems
Part II. Monitoring the dynamic production of glucose and ethanol from microchip-immobilised yeast cells using enzymatic chemiluminescent µ-biosensors

Richard Davidsson, Björn Johansson, Volkmar Passoth, Martin Bengtsson, Thomas Laurell and Jenny Emnéus,  Lab Chip, 2004, 4, 488
DOI: 10.1039/b400900b

Cell lysis on a microfluidic CD (compact disc)
Jitae Kim, Seh Hee Jang, Guangyao Jia, Jim V. Zoval, Nancy A. Da Silva and Marc J. Madou,  Lab Chip, 2004, 4, 516
DOI: 10.1039/b401106f