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27 January 2010
Dana Spence discusses the role of red blood cells in diseases such as diabetes and multiple sclerosis and the importance of a foundation in Chemistry
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Contents list for Integrative Biology, issue 1, 2010
Front cover
Integr. Biol., 2010, 2, 1
DOI: 10.1039/b926416g
Contents
Integr. Biol., 2010, 2, 3
DOI: 10.1039/b926417p
Editorial
Integrative Biology Editorial 2010
Integr. Biol., 2010, 2, 9
DOI: 10.1039/b923760g
Mina Bissell, Editorial Board Chair, on progress and the future as Integrative Biology moves into its second year.
Profile
Interview with Roger Tsien: a glowing career
Integr. Biol., 2010, 2, 10
DOI: 10.1039/b926006b
From jellyfish to cancer diagnostics, Roger Tsien discusses the challenges of looking into a cell with Harp Minhas. Reported by Leanne Marle.
Critical Review
Synthetic biology in the analysis and engineering of signaling processes
Michael M. Kämpf and Wilfried Weber,
Integr. Biol., 2010, 2, 12
DOI: 10.1039/b913490e
This review article highlights the impact of synthetic biology in signaling science—from understanding natural signaling pathways to the design of novel signaling systems.
Frontier
New insights into F-pilus structure, dynamics, and function
Philip M. Silverman and Margaret B. Clarke,
Integr. Biol., 2010, 2, 25
DOI: 10.1039/b917761b
Enhanced HTML article available
The application of modern imaging technologies suggests new insights into the function of conjugative pili in horizontal gene transfer among Gram-negative bacteria.
Papers
A synthetic strategy for mimicking the extracellular matrix provides new insight about tumor cell migration
Michael P. Schwartz, Benjamin D. Fairbanks, Robert E. Rogers, Rajagopal Rangarajan, Muhammad H. Zaman and Kristi S. Anseth,
Integr. Biol., 2010, 2, 32
DOI: 10.1039/b912438a
A synthetic hydrogel is used to study cancer cell migration in 3D and the discovery of an apparently unique migration mode demonstrates the potential usefulness of an engineering strategy for investigating biological phenomena.
In silico evolutionary dynamics of tumour virotherapy
Carlos L. Reis, Jorge M. Pacheco, Matthew K. Ennis and David Dingli,
Integr. Biol., 2010, 2, 41
DOI: 10.1039/b917597k
The authors study the impact of tumour architecture on the outcome of therapy with a recombinant measles virus by combining stochastic tumour growth with cell-to-cell spread of the oncolytic virus.
Simultaneous quantitative monitoring of drug-induced caspase cascade pathways in carcinoma cells
Pravin K. Naoghare, Hyeon A. Ki, Seung-Mann Paek, Yu Kyung Tak, Young-Ger Suh, Sang Geon Kim, Kyeong-Hee Lee and Joon Myong Song,
Integr. Biol., 2010, 2, 46
DOI: 10.1039/b916481b
Simultaneous monitoring of caspase cascades. The developed concept may have fundamental significance in establishing image-based assays for elucidating simultaneous cellular events.
Study of Na+/H+ exchange-mediated pHi regulations in neuronal soma and neurites in compartmentalized microfluidic devices
Lucas Vitzthum, Xinzhi Chen, Douglas B. Kintner, Yu Huang, Shing-Yan Chiu, Justin Williams and Dandan Sun,
Integr. Biol., 2010, 2, 58
DOI: 10.1039/b918440f
Embryonic neuronal progenitors were cultured in PDMS microfluidic devices with soma growing in one chamber and processes extending through a set of perpendicular microchannels into the opposite parallel chamber.
Back matter
Integr. Biol., 2010, 2, 65
DOI: 10.1039/b926419c
Back cover
Integr. Biol., 2010, 2, 67
DOI: 10.1039/b926418n
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