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Activating peptides to target cancer cells
12 May 2009
Activatable cell penetrating peptides are unlocking new opportunities for targeted entry to cancer cells, say Roger Tsien and colleagues
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Contents list for Integrative Biology, issue 7, 2009
Front cover
Integr. Biol., 2009, 1, 437
DOI: 10.1039/b911809h
Inside front cover
Integr. Biol., 2009, 1, 438
DOI: 10.1039/b911811j
Contents
Integr. Biol., 2009, 1, 439
DOI: 10.1039/b911813f
Editorial
Introducing a new Method section for Integrative Biology
Integr. Biol., 2009, 1, 445
DOI: 10.1039/b911214f
David Beebe and Larissa Cheran introduce a new type of article for the journal.
Focus
Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications
Dominique A. Rothenfluh and Jeffrey A. Hubbell,
Integr. Biol., 2009, 1, 446
DOI: 10.1039/b907627c
Enhanced HTML article available
Polymeric nanoparticles have evolved to interact with biological microenvironments and systems in a controlled and specific way—part of a series of mini-reviews covering integration of new tools and technologies for the benefit of biology.
Papers
Nanomechanical sequencing of collagen: tropocollagen features heterogeneous elastic properties at the nanoscale
Sebastien G. M. Uzel and Markus J. Buehler,
Integr. Biol., 2009, 1, 452
DOI: 10.1039/b906864c Enhanced HTML article available
Here we report a systematic computational sequencing of the effect of amino acid motif variations on the mechanical properties of single tropocollagen molecules, and show that variations in the amino acid motif severely influence the elastic behavior of tropocollagen molecules, leading to softening or stiffening behavior.
Directing hepatic differentiation of embryonic stem cells with protein microarray-based co-cultures
Ji Youn Lee, Nazgul Tuleuova, Caroline N. Jones, Erlan Ramanculov, Mark A. Zern and Alexander Revzin,
Integr. Biol., 2009, 1, 460
DOI: 10.1039/b905757a Enhanced HTML article available
We describe a novel method for creating micropatterned co-cultures of embryonic stem cells and hepatocytes based on printed arrays of cell-adhesive ligands.
Adhesion and migration of ovarian cancer cells on crosslinked laminin fibers nanofabricated by multiphoton excited photochemistry
Xiyi Chen, Molly A. Brewer, Changping Zou and Paul J. Campagnola,
Integr. Biol., 2009, 1, 469
DOI: 10.1039/b906310b Enhanced HTML article available
We investigated the adhesion and migration dynamics of human ovarian cancer cells as a function of metastatic potential. Increased migration via contact guidance and decreased adhesion are associated with the more metastatic cells, suggesting these characteristics are operative in vivo.
Method
Dielectric characterization of complete mononuclear and polymorphonuclear blood cell subpopulations for label-free discrimination
Daynene M. Vykoukal, Peter R. C. Gascoyne and Jody Vykoukal,
Integr. Biol., 2009, 1, 477
DOI: 10.1039/b906137a Enhanced HTML article available
Native dielectric properties of the six major leukocyte subpopulations were determined by using a microscale dielectrophoresis-based characterization system to analyze cohorts of individual cells from carefully purified blood cell isolates.
Chemical Biology and Back matter
Integr. Biol., 2009, 1, 485
DOI: 10.1039/b911814b
Back cover
Integr. Biol., 2009, 1, 487
DOI: 10.1039/b911815m
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