(1) Could you explain the significance of your article to the non-specialist?

Biomaterials provide structural building blocks and functional properties that are difficult or impossible to replicate using current synthetic methodology. In our study, we used DNA to provide controlled assembly of magnetic nanoparticles. In these assemblies, the DNA regulates interparticle spacing, providing control over the magnetic properties of the resulting materials. 

Professor Vincent Rotello

(2) What has motivated you to conduct this work?

Integration of biomolecular structure and function with nanomaterials provides a highly promising approach to creating highly complex functional systems. DNA provides an attractive building block for this strategy due to its structure and highly specific recognition properties. 

(3) Where do you see this work developing in the future?

This current study uses the structure but not the coding capabilities of the DNA. Future research will use the high specificity of DNA recognition to provide programmed assembly of complex materials. 

(4) Are there any particular challenges facing future research in this area?

The key challenge for the field of bionanotechnology is the proper engineering of the interface between the biomolecule and the synthetic construct. Non-specific interactions, denaturation, and other concerns very often compromise the function of the overall system. Controlling the interface requires an understanding of biology, synthesis, and materials science, making this a highly fruitful frontier for interdisciplinary science.