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Lab on a Chip

Microfluidic and nanotechnologies for chemistry, biology, and bioengineering



Chips & Tips



Welcome to Chips & Tips - a unique and regularly updated forum for scientists in the miniaturisation field.  Chips & Tips aims to provide a place where ideas and solutions can be exchanged on common practical problems encountered in the lab, which are seldom reported in the literature.

Do you
. have problems with bubble formation when injecting your sample?
. wish there was a quicker way to make prototypes?
. find connecting chips to pumps and syringes problematic?
Or
. do you have your own tricks to overcome these or similar problems? 

If so, then Chips & Tips is the forum to address your requirements.  

Read the tips below or see the author guidelines on how to submit your own today!

Chips & Tips Moderators

David Beebe and Glenn Walker


PDMS rings

Chips & Tips: Reusable, robust NanoPort connections to PDMS chips

08 October 2008

Jesse Greener and colleagues describe how to make reusable, robust NanoPort connections to PDMS chips


electrodes crossing a microchannel

Chips & Tips: Rapid prototyping of a PMMA microfluidic chip with integrated platinum electrodes

18 September 2008

Martin Arundell and co-workers report a method for rapid prototyping of PMMA microfluidic chips with integrated platinum electrodes


PDMS drop

Chips & Tips: Bonding & Sealing of components in PDMS by deposition of micro-drops of PDMS using micropipette

09 September 2008

Arash Noori and P. Ravi Selvaganapathy describe a method for bonding and sealing of components in PDMS


laminated chip

Chips & Tips: Lamination of Plastic Microfluidic Devices

30 July 2008

Daniel Olivero and Z. Hugh Fan present a simple method for lamination of plastic microfluidic devices


microfluidic channel

Chips & Tips: Quick Measurement of Electroosmotic Flow Velocity

10 July 2008

Motohiko Nohmi and Juan Santiago present a simple way of estimating electroosmotic flow velocities in channel geometries with at least one intersection.


holes in a PDMS block

Chips & Tips: See where to punch holes easily in a PDMS microfluidic device

29 May 2008

Amy Rowat and David Weitz describe how to see where to punch holes in a PDMS microfluidic device.


filled reservoirs

Chips & Tips: Integrated Reservoirs for PDMS Microfluidic Chips

22 April 2008

T. Liu and co-workers present integrated reservoirs for PDMS microfluidic chips.


syringe

Chips & Tips: An easy temperature control system for syringe pumps

22 April 2008

Lorenzo Capretto and co-workers describe an easy temperature control system for syringe pumps.


on-chip filter

Chips & Tips: Microfabrication Design Guidelines for Glass Micro- and Nano-fluidic Devices

18 April 2008

Dave Huber and Sumita Pennathur give some useful microfabrication design guidelines for glass micro- and nano-fluidic devices.


bonded Upchurch Nanoport

Chips & Tips: Bonding Upchurch® NanoPorts to PDMS

12 February 2008

Corey Koch and co-workers describe a simple method to bond Upchurch® NanoPortsT to PDMS chips.


Smooth via

Chips & Tips: Magnets for facile molding of via holes in PDMS

06 February 2008

Corey Koch and co-workers describe the use of magnetic molds for construction of complex PDMS devices


PDMS seal for glass chip

Chips & Tips: A foolproof method for enclosing glass-based LOC devices for electrophoresis

16 January 2008

Colin Mansfield and co-workers describe a simple method to produce a leak free and easily reusible device for electrophoresis.


Solvent reservoir

Chips & Tips: Organic Solvent Compatible Reservoirs for Glass Microfluidic Chips

06 December 2007

Michael Watson and Aaron Wheeler describe an alternative to using non-solvent resistant adhesives to attach reservoirs to microfludic chips.


preventing suspension settling during injection

Chips & Tips: Preventing suspension settling during injection

21 August 2007

Ryan Cooper and Luke Lee describe how to avoid settling of suspensions during injection onto a chip.


tubing connector

Chips & Tips: Quick and cheap syringe-tubing interfacing

26 June 2007

Rodrigo Martinez-Duarte and Marc Madou describe a simple method to connect syringes to chips.


On-chip electrophoresis

Chips & Tips: On-chip Electrophoresis Devices: Do's, Don'ts and Dooms

26 March 2007

Juan Santiago and co-workers provide some simple rules of thumb for success in on-chip electrophoresis


exploded view of multilayer chip

Chips & Tips: Rapid Prototyping of microfluidics

15 February 2007

Richard Holmes and Nicholas Goddard describe rapid prototyping of microfluidic systems using double sided tape.


surface plot from video image manipulation

Chips & Tips: Superior data presentation of poor quality microfluidics images

05 February 2007

Richard Holmes and Nicholas Goddard describe a simple method to manipulate video images of microfluidics for presentation in print.


bubble trouble

Chips & Tips: In-line microfluidic bubble trap

22 November 2006

David Eddington presents a simple in-line bubble trap for microfluidic devices.


Chip-syringe interface

Chips & Tips: A simple interface between a PDMS microfluidic device and a syringe

13 November 2006

Jeonggi Seo and Meng H. Lean present a simple way to connect a syringe to your microfluidic device without the need for adhesive.


bubbles in microfluidic chip

Chips & Tips: Vacuum filling of microfluidic devices

23 October 2006

Ivar Meyvantsson and David Beebe provide a simple method to remove bubbles when filling microfluidic chips.


Preventing bubble injection

Chips & Tips: Avoiding bubble injection by droplet merging

23 October 2006

Edmond Young, Aaron Wheeler and Craig Simmons present an easy way to avoid injecting bubbles along with your sample.


PDMS connector

Chips & Tips: PDMS connectors for macro to microfluidic interfacing

23 October 2006

Swomitra Mohanty, Glennys Mensing and David Beebe report a simple fabrication of PDMS connectors to interface chips with the macro world.


PDMS curing

Chips & Tips: Rapid curing of PDMS for microfluidic applications

23 October 2006

Adrian O'Neill, Jeffrey Soo Hoo and Glenn Walker present a new procedure for the curing of PDMS for microfluidic applications.


Downloadable Files

Author guidelines
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