Issue 5, 2008

Templated assembly in a microfluidic channel by sequential loading of gel modules, containing three distinctly labeled populations of cells (fluorescence microscope image). Image reproduced by permission of George M. Whitesides.
DOI: 10.1039/B719806J

Issue 5, 2008 Inside Cover

Conceptual image showing the principle of stretching a device in order to tune it. Image reproduced by permission of Jason P. Beech.
DOI: 10.1039/B805964K

Issue 4, 2008

Continuous, one-step purification of proteins using liquid-liquid extraction in a microfluidic chip. Proteins are genetically engineered to carry a partition tag that allows their purification by selective partitioning in a PEG-salt two-phase system. (E. Coli image reproduced from the US NIH-NIAID image library (credit: Rocky Mountain Laboratories) and protein structures PDB ID: 2HGD, 1L56 and 1U87 from the RCSB PDB.) Image reproduced by permission of A Singh and
R Meagher.
DOI: 10.1039/b716462a

Issue 4, 2008 Inside Cover

Chaotic mixing patterns are generated by micro-actuators, integrated in microfluidic channels. This method was inspired by micro-organisms such as Paramecium, propelling themselves by actuated cilia (micro-hairs) that cover their surface. Image designed by H Herps and reproduced by permission of J den Toonder.
DOI: 10.1039/b804218g

Issue 3, 2008

A microfluidic device against a backdrop of holographically featured photonic crystal that is built in microfluidic channels. The optofluidic integration allows fine tuning of photonic bandgaps. Image reproduced by permission of S-M Yang.
DOI: 10.1039/b717960j

Issue 3, 2008 Inside Cover

Bead-based microfluidic immunoassay integrated with electrokinetic preconcentration for pre-binding enhancement. Target molecules are preconcentrated before primary immuno-binding reaction for improved sensitivity and dynamic
range of detection. Image reproduced by permission of J Han.
DOI: 10.1039/b802443j

Issue 2, 2008

A microfluidic device is used to address the fundamental mechanism of how neurons respond to complex microenvironments.  Images designed by C J Wang and X Li, and reproduced by permission of A Levchenko.
DOI: 10.1039/b713945d

Issue 2, 2008 Inside Cover

A step pattern (red) convolved with microfluidic blurring (blue) deposits protein (purple).  A fitted deposition model convolved with the desired pattern drives syringes to create a 1-D protein pattern. Image reproduced by permission of J Wikswo.
DOI: 10.1039/b800757h

Issue 1, 2008

A microfluidic device to effect gene transfer into single stem cells using electroporation.  Images prepared by J Huijben, and reproduced by permission of A van den Berg.
DOI: 10.1039/b713420g

Issue 1, 2008 Inside Cover

Yeast cell patterned on the surface of an integrated circuit/microfluidic chip. Image reproduced by permission of R Westervelt.
DOI: 10.1039/b718694k