_tcm18-11405.gif )
Miniaturisation for chemistry, physics, biology and bioengineering
Hot Articles
Hot articles are identified by reviewers as significant or newsworthy.
Manufacturable plastic microfluidic valves using thermal actuation
Karthik Pitchaimani, Brian C. Sapp, Adam Winter, Austin Gispanski, Toshikazu Nishida and Z. Hugh Fan, Lab Chip, 2009, 9, 3082
DOI: 10.1039/b909742b
Patterning of superhydrophobic paper to control the mobility of micro-liter drops for two-dimensional lab-on-paper applications
Balamurali Balu, Adam D. Berry, Dennis W. Hess and Victor Breedveld, Lab Chip, 2009, 9, 3066
DOI: 10.1039/b909868b
Rapid switching of chemical signals in microfluidic devices
Albert J. Bae, Carsten Beta and Eberhard Bodenschatz, Lab Chip, 2009, 9, 3059
DOI: 10.1039/b905521e
Lab-on-Chip for fast 3D particle tracking in living cells
Houssam Hajjoul, Silvia Kocanova, Imen Lassadi, Kerstin Bystricky and Aurélien Bancaud, Lab Chip, 2009, 9, 3054
DOI: 10.1039/b909016a
Multi-step microfluidic droplet processing: kinetic analysis of an in vitro translated enzyme
Linas Mazutis, Jean-Christophe Baret, Patrick Treacy, Yousr Skhiri, Ali Fallah Araghi, Michael Ryckelynck, Valérie Taly and Andrew D. Griffiths, Lab Chip, 2009, 9, 2902
DOI: 10.1039/b907753g
Prediction of trapping zones in an insulator-based dielectrophoretic device
Javier L. Baylon-Cardiel, Blanca H. Lapizco-Encinas, Claudia Reyes-Betanzo, Ana V. Chávez-Santoscoy and Sergio O. Martínez-Chapa, Lab Chip, 2009, 9, 2896
DOI: 10.1039/b906976c
Acoustic tweezers: patterning cells and microparticles using standing surface acoustic waves (SSAW)
Jinjie Shi, Daniel Ahmed, Xiaole Mao, Sz-Chin Steven Lin, Aitan Lawit and Tony Jun Huang, Lab Chip, 2009, 9, 2890
DOI: 10.1039/b910595f
Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry
David Holmes, David Pettigrew, Christian H. Reccius, James D. Gwyer, Cees van Berkel, Judith Holloway, Donna E. Davies and Hywel Morgan, Lab Chip, 2009, 9, 2881
DOI: 10.1039/b910053a
An acoustically-driven biochip – impact of flow on the cell-association of targeted drug carriers
Christian Fillafer, Gerda Ratzinger, Jürgen Neumann, Zeno Guttenberg, Silke Dissauer, Irene K. Lichtscheidl, Michael Wirth, Franz Gabor and Matthias F. Schneider, Lab Chip, 2009, 9, 2782
DOI: 10.1039/b906006e
Thin, lightweight, foldable thermochromic displays on paper
Adam C. Siegel, Scott T. Phillips, Benjamin J. Wiley and George M. Whitesides, Lab Chip, 2009, 9, 2775
DOI: 10.1039/b905832j
Automated high-throughput cell microsurgery on-chip
Kwanghun Chung and Hang Lu, Lab Chip, 2009, 9, 2764
DOI: 10.1039/b910703g
Multiple modular microfluidic (M3) reactors for the synthesis of polymer particles
Wei Li, Jesse Greener, Dan Voicu and Eugenia Kumacheva, Lab Chip, 2009, 9, 2715
DOI: 10.1039/b906626h
Active pixel sensor array for high spatio-temporal resolution electrophysiological recordings from single cell to large scale neuronal networks
Luca Berdondini, Kilian Imfeld, Alessandro Maccione, Mariateresa Tedesco, Simon Neukom, Milena Koudelka-Hep and Sergio Martinoia, Lab Chip, 2009, 9, 2644
DOI: 10.1039/b907394a
High-throughput design of microfluidics based on directed bacterial motility
Bryan Kaehr and Jason B. Shear, Lab Chip, 2009, 9, 2632
DOI: 10.1039/b908119d
Neuro-optical microfluidic platform to study injury and regeneration of single axons
Young-tae Kim, Kailash Karthikeyan, Sajal Chirvi and Digant P. Davé, Lab Chip, 2009, 9, 2576
DOI: 10.1039/b903720a
Separation of particles by pulsed dielectrophoresis
Hai-Hang Cui, Joel Voldman, Xue-Fei He and Kian-Meng Lim, Lab Chip, 2009, 9, 2306
DOI: 10.1039/b906202e
A microfluidic apparatus for the study of ice nucleation in supercooled water drops
Claudiu A. Stan, Grégory F. Schneider, Sergey S. Shevkoplyas, Michinao Hashimoto, Mihai Ibanescu, Benjamin J. Wiley and George M. Whitesides, Lab Chip, 2009, 9, 2293
DOI: 10.1039/b906198c
SlipChip
Wenbin Du, Liang Li, Kevin P. Nichols and Rustem F. Ismagilov, Lab Chip, 2009, 9, 2286
DOI: 10.1039/b908978k
An integrated microfluidic device for large-scale in situ click chemistry screening
Yanju Wang, Wei-Yu Lin, Kan Liu, Rachel J. Lin, Matthias Selke, Hartmuth C. Kolb, Nangang Zhang, Xing-Zhong Zhao, Michael E. Phelps, Clifton K. F. Shen, Kym F. Faull and Hsian-Rong Tseng, Lab Chip, 2009, 9, 2281
DOI: 10.1039/b907430a
Sorting directionally oriented microstructures using railed microfluidics
Wook Park, Hosuk Lee, Hyungsung Park and Sunghoon Kwon, Lab Chip, 2009, 9, 2169
DOI: 10.1039/b904153b
Label-free silicon photonic biosensor system with integrated detector array
Rongjin Yan, Santano P. Mestas, Guangwei Yuan, Rashid Safaisini, David S. Dandy and Kevin L. Lear, Lab Chip, 2009, 9, 2163
DOI: 10.1039/b902111f
Isolation, incubation, and parallel functional testing and identification by FISH of rare microbial single-copy cells from multi-species mixtures using the combination of chemistrode and stochastic confinement
Weishan Liu, Hyun Jung Kim, Elena M. Lucchetta, Wenbin Du and Rustem F. Ismagilov, Lab Chip, 2009, 9, 2153
DOI: 10.1039/b904958d
Inkjet formation of unilamellar lipid vesicles for cell-like encapsulation
Jeanne C. Stachowiak, David L. Richmond, Thomas H. Li, Françoise Brochard-Wyart and Daniel A. Fletcher, Lab Chip, 2009, 9, 2003
DOI: 10.1039/b904984c
Dynamic bioprocessing and microfluidic transport control with smart magnetic nanoparticles in laminar-flow devices
James J. Lai, Kjell E. Nelson, Michael A. Nash, Allan S. Hoffman, Paul Yager and Patrick S. Stayton, Lab Chip, 2009, 9, 1997
DOI: 10.1039/b817754f
A novel lab-on-a-tube for multimodality neuromonitoring of patients with traumatic brain injury (TBI)
Chunyan Li, Pei-Ming Wu, WooSeok Jung, Chong H. Ahn, Lori A. Shutter and Raj K. Narayan, Lab Chip, 2009, 9, 1988
DOI: 10.1039/b900651f
Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity
Jean-Christophe Baret, Oliver J. Miller, Valerie Taly, Michaël Ryckelynck, Abdeslam El-Harrak, Lucas Frenz, Christian Rick, Michael L. Samuels, J. Brian Hutchison, Jeremy J. Agresti, Darren R. Link, David A. Weitz and Andrew D. Griffiths, Lab Chip, 2009, 9, 1850
DOI: 10.1039/b902504a
Distillation in microchemical systems using capillary forces and segmented flow
Ryan L. Hartman, Hemantkumar R. Sahoo, Bernard C. Yen and Klavs F. Jensen, Lab Chip, 2009, 9, 1843
DOI: 10.1039/b901790a
Simultaneous measurement of reactions in microdroplets filled by concentration gradients
Nicolae Damean, Luis F. Olguin, Florian Hollfelder, Chris Abell and Wilhelm T. S. Huck, Lab Chip, 2009, 9, 1707
DOI: 10.1039/b821021g
A microfluidic chip for electrochemical conversions in drug metabolism studies
M. Odijk, A. Baumann, W. Lohmann, F. T. G. van den Brink, W. Olthuis, U. Karst and A. van den Berg, Lab Chip, 2009, 9, 1687
DOI: 10.1039/b822962g
High-radix microfluidic multiplexer with pressure valves of different thresholds
Dong Woo Lee and Young-Ho Cho, Lab Chip, 2009, 9, 1681
DOI: 10.1039/b820582e
Microfluidic chip for combinatorial mixing and screening of assays
Benjamin R. Schudel, Charles J. Choi, Brian T. Cunningham and Paul J. A. Kenis, Lab Chip, 2009, 9, 1676
DOI: 10.1039/b901999e
Three-dimensional fabrication of heterogeneous microstructures using soft membrane deformation and optofluidic maskless lithography
Seung Ah Lee, Su Eun Chung, Wook Park, Sung Hoon Lee and Sunghoon Kwon, Lab Chip, 2009, 9, 1670
DOI: 10.1039/b819999j
An air-bubble-actuated micropump for on-chip blood transportation
Sheng-Hung Chiu and Cheng-Hsien Liu, Lab Chip, 2009, 9, 1524
DOI: 10.1039/b900139e
Serial DNA immobilization in micro- and extended nanospace channels
Björn Renberg, Kae Sato, Kazuma Mawatari, Naokazu Idota, Takehiko Tsukahara and Takehiko Kitamori, Lab Chip, 2009, 9, 1517
DOI: 10.1039/b823436a
An array of ordered pillars with retentive properties for pressure-driven liquid chromatography fabricated directly from an unmodified cyclo olefin polymer
Xavi Illa, Wim De Malsche, Johan Bomer, Han Gardeniers, Jan Eijkel, Joan Ramon Morante, Albert Romano-Rodríguez and Gert Desmet, Lab Chip, 2009, 9, 1511
DOI: 10.1039/b818918h
Controlled capture and release of cardiac fibroblasts using peptide-functionalized alginate gels in microfluidic channels
Brian D. Plouffe, Melissa A. Brown, Rohin K. Iyer, Milica Radisic and Shashi K. Murthy, Lab Chip, 2009, 9, 1507
DOI: 10.1039/b823523f
On-demand microfluidic droplet trapping and fusion for on-chip static droplet assays
Wei Wang, Chun Yang and Chang Ming Li, Lab Chip, 2009, 9, 1504
DOI: 10.1039/b903468d
An integrated hybrid interference and absorption filter for fluorescence detection in lab-on-a-chip devices
Charles Richard, Alan Renaudin, Vincent Aimez and Paul G. Charette, Lab Chip, 2009, 9, 1371
DOI: 10.1039/b819080a
Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics
Xuanhong Cheng, Amit Gupta, Chihchen Chen, Ronald G. Tompkins, William Rodriguez and Mehmet Toner, Lab Chip, 2009, 9, 1357
DOI: 10.1039/b818813k
A travelling wave dielectrophoretic pump for blood delivery
U. Lei, C.W. Huang, James Chen, C.Y. Yang, Y.J. Lo, Andrew Wo, C.F. Chen and T.W. Fung, Lab Chip, 2009, 9, 1349
DOI: 10.1039/b822809d
Reliable microfluidic on-chip incubation of droplets in delay-lines
Lucas Frenz, Kerstin Blank, Eric Brouzes and Andrew D. Griffiths, Lab Chip, 2009, 9, 1344
DOI: 10.1039/b816049j
Microvalve-actuated precise control of individual droplets in microfluidic devices
Shaojiang Zeng, Bowei Li, Xiao
ou Su, Jianhua Qin and Bingcheng Lin, Lab Chip, 2009, 9, 1340
DOI: 10.1039/b821803j
Optical redistribution of microparticles and cells between microwells
Jörg Baumgartl, Gregor M. Hannappel, David J. Stevenson, Daniel Day, Min Gu and Kishan Dholakia, Lab Chip, 2009, 9, 1334
DOI: 10.1039/b901322a
Selection and elution of aptamers using nanoporous sol-gel arrays with integrated microheaters
Seung-min Park, Ji-Young Ahn, Minjoung Jo, Dong-ki Lee, John T. Lis, Harold G. Craighead and Soyoun Kim, Lab Chip, 2009, 9, 1206
DOI: 10.1039/b814993c
A facile 
liquid-molding
method to fabricate PDMS microdevices with 3-dimensional channel topography
Xin Liu, Qi Wang, Jianhua Qin and Bingcheng Lin, Lab Chip, 2009, 9, 1200
DOI: 10.1039/b818721e
Entrapment and measurement of a biologically functionalized microbead with a microwell electrode
Ching-Yu Chang, Yasufumi Takahashi, Tatsuya Murata, Hitoshi Shiku, Hsien-Chang Chang and Tomokazu Matsue, Lab Chip, 2009, 9, 1185
DOI: 10.1039/b817705h
Modelling and optimization of micro optofluidic lenses
Chaolong Song, Nam-Trung Nguyen, Say-Hwa Tan and Anand Krishna Asundi, Lab Chip, 2009, 9, 1178
DOI: 10.1039/b819158a
Micromagnetic–microfluidic blood cleansing device
Chong Wing Yung, Jason Fiering, Andrew J. Mueller and Donald E. Ingber, Lab Chip, 2009, 9, 1171
DOI: 10.1039/b816986a
Direct projection on dry-film photoresist (DP2): do-it-yourself three-dimensional polymer microfluidics
Siwei Zhao, Hailin Cong and Tingrui Pan, Lab Chip, 2009, 9, 1128
DOI: 10.1039/b817925e
Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures
Mark Polinkovsky, Edgar Gutierrez, Andre Levchenko and Alex Groisman, Lab Chip, 2009, 9, 1073
DOI: 10.1039/b816191g
DNA methylation analysis on a droplet-in-oil PCR array
Yi Zhang, Vasudev Bailey, Christopher M. Puleo, Hariharan Easwaran, Elizabeth Griffiths, James G. Herman, Stephen B. Baylin and Tza-Huei Wang, Lab Chip, 2009, 9, 1059
DOI: 10.1039/b821780g
Microfluidic device using chemiluminescence and a DNA-arrayed thin film transistor photosensor for single nucleotide polymorphism genotyping of PCR amplicons from whole blood
Keiichi Hatakeyama, Tsuyoshi Tanaka, Masahiro Sawaguchi, Akihito Iwadate, Yasushi Mizutani, Kazuhiro Sasaki, Naofumi Tateishi and Tadashi Matsunaga, Lab Chip, 2009, 9, 1052
DOI: 10.1039/b817427j
Hybrid microfluidics: A digital-to-channel interface for in-line sample processing and chemical separations
Mohamed Abdelgawad, Michael W. L. Watson and Aaron R. Wheeler, Lab Chip, 2009, 9, 1046
DOI: 10.1039/b820682a
Controlling the selection stringency of phage display using a microfluidic device
Yanli Liu, Jonathan D. Adams, Kelisha Turner, Frank V. Cochran, Sanjiv Sam Gambhir and H. Tom Soh, Lab Chip, 2009, 9, 1033
DOI: 10.1039/b820985e
DEP actuated nanoliter droplet dispensing using feedback control
Kai-Liang Wang, Thomas B. Jones and Alan Raisanen, Lab Chip, 2009, 9, 901
DOI: 10.1039/b816438j
The BAD project: data mining, database and prediction of protein adsorption on surfaces
Elena N. Vasina, Ewa Paszek and Dan V. Nicolau, Jr and Dan V. Nicolau, Lab Chip, 2009, 9, 891
DOI: 10.1039/b813475h
Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip
Tsi-Hsuan Hsu, Meng-Hua Yen, Wei-Yu Liao, Ji-Yen Cheng and Chau-Hwang Lee, Lab Chip, 2009, 9, 884
DOI: 10.1039/b814405b
Use of photopatterned porous polymer monoliths as passive micromixers to enhance mixing efficiency for on-chip labeling reactions
Dieudonne A. Mair, Thomas R. Schwei, Theresa S. Dinio, Frantisek Svec and Jean M. J. Fréchet, Lab Chip, 2009, 9, 877
DOI: 10.1039/b816521a
A new USP Class VI-compliant substrate for manufacturing disposable microfluidic devices
Jason S. Kuo, Laiying Ng, Gloria S. Yen, Robert M. Lorenz, Perry G. Schiro, J. Scott Edgar, Yongxi Zhao, David S. W. Lim, Peter B. Allen, Gavin D. M. Jeffries and Daniel T. Chiu, Lab Chip, 2009, 9, 870
DOI: 10.1039/b818873d
Lock release lithography for 3D and composite microparticles
Ki Wan Bong, Daniel C. Pregibon and Patrick S. Doyle, Lab Chip, 2009, 9, 863
DOI: 10.1039/b821930c
Flow-free transport of cells in microchannels by frequency-modulated ultrasound
O. Manneberg, B. Vanherberghen, B. Önfelt and M. Wiklund, Lab Chip, 2009, 9, 833
DOI: 10.1039/b816675g
Rapid generation of spatially and temporally controllable long-range concentration gradients in a microfluidic device
Yanan Du, Jaesool Shim, Mahesh Vidula, Matthew J. Hancock, Edward Lo, Bong Geun Chung, Jeffrey T. Borenstein, Masoud Khabiry, Donald M. Cropek and Ali Khademhosseini, Lab Chip, 2009, 9, 761
DOI: 10.1039/b815990d
Engineering insect flight metabolics using immature stage implanted microfluidics
Aram J. Chung and David Erickson, Lab Chip, 2009, 9, 669
DOI: 10.1039/b814911a
Optical force sensor array in a microfluidic device based on holographic optical tweezers
Kai Uhrig, Rainer Kurre, Christian Schmitz, Jennifer E. Curtis, Tamás Haraszti, Anabel E.-M. Clemen and Joachim P. Spatz, Lab Chip, 2009, 9, 661
DOI: 10.1039/b817633g
Antigen detection using polymerization-based amplification
Hadley D. Sikes, Robert Jenison and Christopher N. Bowman, Lab Chip, 2009, 9, 653
DOI: 10.1039/b816198d
Parallel multi-time point cell stimulation and lysis on-chip for studying early signaling events in T cell activation
Alison M. Hirsch, Catherine A. Rivet, Boyang Zhang, Melissa L. Kemp and Hang Lu, Lab Chip, 2009, 9, 536
DOI: 10.1039/b810896j
A fluidic device to study directional angiogenesis in complex tissue and organ culture models
Irmeli Barkefors, Sara Thorslund, Fredrik Nikolajeff and Johan Kreuger, Lab Chip, 2009, 9, 529
DOI: 10.1039/b814691h
Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets
Jason R. Butler, Jon B. Wills, Laura Mitchem, Daniel R. Burnham, David McGloin and Jonathan P. Reid, Lab Chip, 2009, 9, 521
DOI: 10.1039/b814545h
A microfluidic droplet generator based on a piezoelectric actuator
Avishay Bransky, Natanel Korin, Maria Khoury and Shulamit Levenberg, Lab Chip, 2009, 9, 516
DOI: 10.1039/b814810d
Isotropically etched radial micropore for cell concentration, immobilization, and picodroplet generation
Thomas D. Perroud, Robert J. Meagher, Michael P. Kanouff, Ronald F. Renzi, Meiye Wu, Anup K. Singh and Kamlesh D. Patel, Lab Chip, 2009, 9, 507
DOI: 10.1039/b817285d
Capillary microreactors wall-coated with mesoporous titania thin film catalyst supports
Evgeny V. Rebrov, Angel Berenguer-Murcia, Helen E. Skelton, Brian F. G. Johnson, Andrew. E. H. Wheatley and Jaap C. Schouten, Lab Chip, 2009, 9, 503
DOI: 10.1039/b815716b
A screw-actuated pneumatic valve for portable, disposable microfluidics
Yizhe Zheng, Wen Dai and Hongkai Wu, Lab Chip, 2009, 9, 469
DOI: 10.1039/b811526e
A conformal nano-adhesive via initiated chemical vapor deposition for microfluidic devices
Sung Gap Im, Ki Wan Bong, Chia-Hua Lee, Patrick S. Doyle and Karen K. Gleason, Lab Chip, 2009, 9, 411
DOI: 10.1039/b812121d
Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture
Bradley J. Dworak and Bruce C. Wheeler, Lab Chip, 2009, 9, 404
DOI: 10.1039/b806689b
A cooperative polymer-DNA microarray approach to biomaterial investigation
Salvatore Pernagallo, Juan Jose Diaz-Mochon and Mark Bradley, Lab Chip, 2009, 9, 397
DOI: 10.1039/b808363k
Liquid–liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows
Oliver K. Castell, Christopher J. Allender and David A. Barrow, Lab Chip, 2009, 9, 388
DOI: 10.1039/b806946h
Sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding Bragg mirrors for enhanced sensitivity and isolation
Nathan C. Lindquist, Antoine Lesuffleur, Hyungsoon Im and Sang-Hyun Oh, Lab Chip, 2009, 9, 382
DOI: 10.1039/b816735d
Experimentally and theoretically observed native pH shifts in a nanochannel array
Danny Bottenus, Youn-Jin Oh, Sang M. Han and Cornelius F. Ivory, Lab Chip, 2009, 9, 219
DOI: 10.1039/b803278e
Lab-on-a-chip for ultrasensitive detection of carbofuran by enzymatic inhibition with replacement of enzyme using magnetic beads
Xavier Llopis, Martin Pumera, Salvador Alegret and Arben Merkoçi, Lab Chip, 2009, 9, 213
DOI: 10.1039/b816643a
Rapid and selective concentration of microparticles in an optoelectrofluidic platform
Hyundoo Hwang and Je-Kyun Park, Lab Chip, 2009, 9, 199
DOI: 10.1039/b811740c
Optical aggregation of metal nanoparticles in a microfluidic channel for surface-enhanced Raman scattering analysis
Lianming Tong, Maurizio Righini, Maria Ujue Gonzalez, Romain Quidant and Mikael Käll, Lab Chip, 2009, 9, 193
DOI: 10.1039/b813204f
Comprehensive analysis of particle motion under non-uniform AC electric fields in a microchannel
Jonghyun Oh, Robert Hart, Jorge Capurro and Hongseok (Moses) Noh, Lab Chip, 2009, 9, 62
DOI: 10.1039/b801594e
Cell-free protein expression in a microchannel array with passive pumping
Ruba Khnouf, David J. Beebe and Z. Hugh Fan, Lab Chip, 2009, 9, 56
DOI: 10.1039/b808034h
High-pressure needle interface for thermoplastic microfluidics
C. F. Chen, J. Liu, L. P. Hromada, C. W. Tsao, C. C. Chang and D. L. DeVoe, Lab Chip, 2009, 9, 50
DOI: 10.1039/b812812j
Dropspots: a picoliter array in a microfluidic device
Christian H. J. Schmitz, Amy C. Rowat, Sarah Köster and David A. Weitz, Lab Chip, 2009, 9, 44
DOI: 10.1039/b809670h
