Lab on a Chip

Miniaturisation for chemistry, physics, biology and bioengineering



Hot articles 2008


Lab on a Chip hot articles from 2008 are available to browse here

Live cell lithography: Using optical tweezers to create synthetic tissue
Utkur Mirsaidov, Jan Scrimgeour, Winston Timp, Kaethe Beck, Mustafa Mir, Paul Matsudaira and Gregory Timp, Lab Chip, 2008, 8, 2174
DOI: 10.1039/b807987k


Sequential enzymatic glycosyltransfer reactions on a microfluidic device: Synthesis of a glycosaminoglycan linkage region tetrasaccharide
Yasunari Ono, Motohiro Kitajima, Shusaku Daikoku, Toshifumi Shiroya, Shoko Nishihara, Yoshimi Kanie, Katsuhiko Suzuki, Satoshi Goto and Osamu Kanie, Lab Chip, 2008, 8, 2168
DOI: 10.1039/b809316d


Patterning protein concentration using laser-assisted adsorption by photobleaching, LAPAP
Jonathan M. Bélisle, James P. Correia, Paul W. Wiseman, Timothy E. Kennedy and Santiago Costantino, Lab Chip, 2008, 8, 2164
DOI: 10.1039/b813897d


Surface patterning of (bio)molecules onto the inner wall of fused-silica capillary tubes
Nabil Dendane, Antoine Hoang, Olivier Renaudet, Françoise Vinet, Pascal Dumy and Eric Defrancq, Lab Chip, 2008, 8, 2161
DOI: 10.1039/b811786a


FLASH: A rapid method for prototyping paper-based microfluidic devices
Andres W. Martinez, Scott T. Phillips, Benjamin J. Wiley, Malancha Gupta and George M. Whitesides, Lab Chip, 2008, 8, 2146
DOI: 10.1039/b811135a


Enabling a microfluidic immunoassay for the developing world by integration of on-card dry reagent storage
Dean Y. Stevens, Camille R. Petri, Jennifer L. Osborn, Paolo Spicar-Mihalic, Katherine G. McKenzie and Paul Yager, Lab Chip, 2008, 8, 2038
DOI: 10.1039/b811158h


Using ratchets and sorters to fractionate motile cells of Escherichia coli by length
S. Elizabeth Hulme, Willow R. DiLuzio, Sergey S. Shevkoplyas, Linda Turner, Michael Mayer, Howard C. Berg and George M. Whitesides, Lab Chip, 2008, 8, 1888
DOI: 10.1039/b809892a


Rewritable remote encoding and decoding of miniature multi-bit magnetic tags for high-throughput biological analysis
J.-R. Jeong, J. Llandro, Bingyan Hong, T. J. Hayward, T. Mitrelias, K. P. Kopper, T. Trypiniotis, S. J. Steinmuller, G. K. Simpson and J. A. C. Bland, Lab Chip, 2008, 8, 1883
DOI: 10.1039/b807632d


Features of a micro-gas chromatograph equipped with enrichment device and microchip plasma emission detection (PED) for air monitoring
Bart Tienpont, Frank David, Wim Witdouck, Dries Vermeersch, Herbert Stoeri and Pat Sandra, Lab Chip, 2008, 8, 1819
DOI: 10.1039/b811599k


Rapid fluidic exchange microsystem for recording of fast ion channel kinetics in Xenopus oocytes
E. Dahan, V. Bize, T. Lehnert, J.-D. Horisberger and M. A. M. Gijs, Lab Chip, 2008, 8, 1809
DOI: 10.1039/b806404k


Bead-based microfluidic toxin sensor integrating evaporative signal amplification
Megan L. Frisk, Erwin Berthier, William H. Tepp, Eric A. Johnson and David J. Beebe, Lab Chip, 2008, 8, 1793
DOI: 10.1039/b811075a


An active bubble trap and debubbler for microfluidic systems
Alison M. Skelley and Joel Voldman, Lab Chip, 2008, 8, 1733
DOI: 10.1039/b807037g


Biocompatible surfactants for water-in-fluorocarbon emulsions
C. Holtze, A. C. Rowat, J. J. Agresti, J. B. Hutchison, F. E. Angilè, C. H. J. Schmitz, S. Köster, H. Duan, K. J. Humphry, R. A. Scanga, J. S. Johnson, D. Pisignano and D. A. Weitz, Lab Chip, 2008, 8, 1632
DOI: 10.1039/b806706f


Formation of artificial lipid bilayers using droplet dielectrophoresis
Sara Aghdaei, Mairi E. Sandison, Michele Zagnoni, Nicolas G. Green and Hywel Morgan, Lab Chip, 2008, 8, 1617
DOI: 10.1039/b807374k


Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging
Vernella Vickerman, Jennifer Blundo, Seok Chung and Roger Kamm, Lab Chip, 2008, 8, 1468
DOI: 10.1039/b802395f


Open micro-fluidic system for atomic force microscopy-guided in situ electrochemical probing of a single cell
WonHyoung Ryu, Zubin Huang, Joong Sun Park, Jeffrey Moseley, Arthur R. Grossman, Rainer J. Fasching and Fritz B. Prinz, Lab Chip, 2008, 8, 1460
DOI: 10.1039/b803450h


Novel inorganic polymer derived microreactors for organic microchemistry applications
Tae-Ho Yoon, Sang-Hee Park, Kyoung-Ik Min, Xunli Zhang, Stephen J. Haswell and Dong-Pyo Kim, Lab Chip, 2008, 8, 1454
DOI: 10.1039/b804726j


Crossing microfluidic streamlines to lyse, label and wash cells
Keith J. Morton, Kevin Loutherback, David W. Inglis, Ophelia K. Tsui, James C. Sturm, Stephen Y. Chou and Robert H. Austin, Lab Chip, 2008, 8, 1448
DOI: 10.1039/b805614e


Setting up roadblocks for kinesin-1: mechanism for the selective speed control of cargo carrying microtubules
Till Korten and Stefan Diez, Lab Chip, 2008, 8, 1441
DOI: 10.1039/b803585g


Droplet-based microfluidic system for individual Caenorhabditis elegans assay
Weiwei Shi, Jianhua Qin, Nannan Ye and Bingcheng Lin, Lab Chip, 2008, 8, 1432
DOI: 10.1039/b808753a


Microfluidic assembly blocks
Minsoung Rhee and Mark A. Burns, Lab Chip, 2008, 8, 1365
DOI: 10.1039/b805137b


Endothelial cell polarization and chemotaxis in a microfluidic device
Amir Shamloo, Ning Ma, Mu-ming Poo, Lydia L. Sohn and Sarah C. Heilshorn, Lab Chip, 2008, 8, 1292
DOI: 10.1039/b719788h


On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures
Kyohei Terao, Masao Washizu and Hidehiro Oana, Lab Chip, 2008, 8, 1280
DOI: 10.1039/b803753a


Photopolymerized diffusion-defined polyacrylamide gradient gels for on-chip protein sizing
Catherine T. Lo, Daniel J. Throckmorton, Anup K. Singh and Amy E. Herr, Lab Chip, 2008, 8, 1273
DOI: 10.1039/b804485f


Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics
James Q. Boedicker, Liang Li, Timothy R. Kline and Rustem F. Ismagilov, Lab Chip, 2008, 8, 1265
DOI: 10.1039/b804911d


Chemotaxis in microfluidic devices—a study of flow effects
Carsten Beta, Toni Fröhlich, Hendrik U. Bödeker and Eberhard Bodenschatz, Lab Chip, 2008, 8, 1087
DOI: 10.1039/b801331d


Stop-flow lithography to generate cell-laden microgel particles
Priyadarshi Panda, Shamsher Ali, Edward Lo, Bong Geun Chung, T. Alan Hatton, Ali Khademhosseini and Patrick S. Doyle, Lab Chip, 2008, 8, 1056
DOI: 10.1039/b804234a


Microfluidic add-on for standard electrophysiology chambers
Javeed Shaikh Mohammed, Hector Hugo Caicedo, Christopher P. Fall and David T. Eddington, Lab Chip, 2008, 8, 1048
DOI: 10.1039/b802037j


Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics
Kristy M. Ainslie, Casey M. Kraning and Tejal A. Desai, Lab Chip, 2008, 8, 1042
DOI: 10.1039/b800604k


Living cantilever arrays for characterization of mass of single live cells in fluids
Kidong Park, Jaesung Jang, Daniel Irimia, Jennifer Sturgis, James Lee, J. Paul Robinson, Mehmet Toner and Rashid Bashir, Lab Chip, 2008, 8, 1034
DOI: 10.1039/b803601b


Monolithic photolithographically patterned Fluorocur PFPE membrane valves and pumps for in situ planetary exploration
Peter A. Willis, Frank Greer, Michael C. Lee, J. Anthony Smith, Victor E. White, Frank J. Grunthaner, Jacob J. Sprague and Jason P. Rolland, Lab Chip, 2008, 8, 1024
DOI: 10.1039/b804265a


Drug testing on 3D in vitro tissues trapped on a microcavity chip
Daniel Kloß, Michael Fischer, Andrée Rothermel, Jan C. Simon and Andrea A. Robitzki, Lab Chip, 2008, 8, 879
DOI: 10.1039/b800394g


An automatic and quantitative on-chip cell migration assay using self-assembled monolayers combined with real-time cellular impedance sensing
Lei Wang, Jing Zhu, Cheng Deng, Wan-li Xing and Jing Cheng, Lab Chip, 2008, 8, 872
DOI: 10.1039/b804130j


Ultra-sensitive detection of bacterial toxin with silicon nanowire transistor
Nirankar N. Mishra, Wusi C. Maki, Eric Cameron, Ron Nelson, Paul Winterrowd, Shiva K. Rastogi, Brian Filanoski and Gary K. Maki, Lab Chip, 2008, 8, 868
DOI: 10.1039/b802036a


Measuring reaction rates on single particles in a microfluidic device
Meghan M. Caulum and Charles S. Henry, Lab Chip, 2008, 8, 865
DOI: 10.1039/b714822d


Microfluidic device for immunoassays based on surface plasmon resonance imaging
Yiqi Luo, Fang Yu and Richard N. Zare, Lab Chip, 2008, 8, 694
DOI: 10.1039/b800606g


Lab-on-chip methodologies for the study of transport in porous media: energy applications
Viatcheslav Berejnov, Ned Djilali and David Sinton, Lab Chip, 2008, 8, 689
DOI: 10.1039/b802373p


On a chip demonstration of a functional role for odorant binding protein in the preservation of olfactory receptor activity at high odorant concentration
Jasmina Vidic, Jeanne Grosclaude, Régine Monnerie, Marie-Annick Persuy, Karine Badonnel, Christine Baly, Monique Caillol, Loïc Briand, Roland Salesse and Edith Pajot-Augy, Lab Chip, 2008, 8, 678
DOI: 10.1039/b717724k


Fabrication of a modular tissue construct in a microfluidic chip
Derek A. Bruzewicz, Alison P. McGuigan and George M. Whitesides, Lab Chip, 2008, 8, 663
DOI: 10.1039/b719806j


Tuneable separation in elastomeric microfluidics devices
Jason P. Beech and Jonas O. Tegenfeldt, Lab Chip, 2008, 8, 657
DOI: 10.1039/b719449h


Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation
Fei Zeng, Christopher B. Rohde and Mehmet Fatih Yanik, Lab Chip, 2008, 8, 653
DOI: 10.1039/b804808h


Digital microfluidics for cell-based assays
Irena Barbulovic-Nad, Hao Yang, Philip S. Park and Aaron R. Wheeler, Lab Chip, 2008, 8, 519
DOI: 10.1039/b717759c


Glass coating for PDMS microfluidic channels by sol–gel methods
Adam R. Abate, Daeyeon Lee, Thao Do, Christian Holtze and David A. Weitz, Lab Chip, 2008, 8, 516
DOI: 10.1039/b800001h


Examination of laser microbeam cell lysis in a PDMS microfluidic channel using time-resolved imaging
Pedro A. Quinto-Su, Hsuan-Hong Lai, Helen H. Yoon, Christopher E. Sims, Nancy L. Allbritton and Vasan Venugopalan, Lab Chip, 2008, 8, 408
DOI: 10.1039/b715708h


Rapid sacrificial layer etching for the fabrication of nanochannels with integrated metal electrodes
Wouter Sparreboom, Jan C. T. Eijkel, Johan Bomer and Albert van den Berg, Lab Chip, 2008, 8, 402
DOI: 10.1039/b716382g


Dynamically reconfigurable liquid-core liquid-cladding lens in a microfluidic channel
Sindy K. Y. Tang, Claudiu A. Stan and George M. Whitesides, Lab Chip, 2008, 8, 395
DOI: 10.1039/b717037h


A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues
C. Joanne Wang, Xiong Li, Benjamin Lin, Sangwoo Shim, Guo-li Ming and Andre Levchenko, Lab Chip, 2008, 8, 227
DOI: 10.1039/b713945d


A microfluidic bioreactor for increased active retrovirus output
Halong N. Vu, Yawen Li, Monica Casali, Daniel Irimia, Zaki Megeed and Martin L. Yarmush, Lab Chip, 2008, 8, 75
DOI: 10.1039/b711577f


Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device
A. Valero, J. N. Post, J. W. van Nieuwkasteele, P. M. ter Braak, W. Kruijer and A. van den Berg, Lab Chip, 2008, 8, 62
DOI: 10.1039/b713420g