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Lab on a Chip

Miniaturisation for chemistry, physics, biology and bioengineering



An Issue for Tissue


05 June 2007

Cover of issue 6
Always keen to break new ground and find the latest cutting edge research in innovative areas, LOC has turned its attention to the exciting field of tissue engineering. 

 

Lab on a Chip commissioned Editorial Board member Sangeeta Bhatia (MIT) and Christopher Chen (University of Pennsylvania) to assemble a special issue dedicated to novel, state-of-the-art research on 'Cell and Tissue Engineering in Microsystems' to better understand tissue engineering principles.

"Tissue engineering is probably the most promising area of biology and biotechnology, this is an excellent issue featuring the best authors at the leading edge of tissue engineering...congratulations to Chris and Sangeeta"
- Andreas Manz, ISAS, Dortmund

 

The results can be seen below, the issue includes a critical review of cell micropatterning techniques; a tutorial review of perfusion culture of mammalian cells; and several high quality full papers on topics covering cell culture, patterning of biomaterials, stem cell differentiation, biocompatible implants, 3D tissue culture, embryoid bodies, cell cytotoxicity analysis and cell-cell communication.

Editorial

Special issue on Cell and Tissue Engineering in Microsystems
Lab Chip, 2007, 7, 666
DOI: 10.1039/b707014b


Contributors to the Lab on a Chip Cell and Tissue Engineering in Microsystems special issue
Lab Chip, 2007, 7, 667
DOI: 10.1039/b707012h


Reviews

Comparative study and improvement of current cell micro-patterning techniques
Jenny Fink, Manuel Théry, Ammar Azioune, Raphael Dupont, François Chatelain, Michel Bornens and Matthieu Piel, Lab Chip, 2007, 7, 672
DOI: 10.1039/b618545b


A practical guide to microfluidic perfusion culture of adherent mammalian cells
Lily Kim, Yi-Chin Toh, Joel Voldman and Hanry Yu, Lab Chip, 2007, 7, 681
DOI: 10.1039/b704602b


Full Papers

Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space
Sarah Tao, Conan Young, Stephen Redenti, Yiqin Zhang, Henry Klassen, Tejal Desai and Michael J. Young, Lab Chip, 2007, 7, 695
DOI: 10.1039/b618583e


Multiphase electropatterning of cells and biomaterials
Dirk R. Albrecht, Gregory H. Underhill, Avital Mendelson and Sangeeta N. Bhatia, Lab Chip, 2007, 7, 702
DOI: 10.1039/b701306j


Micro-bioreactor array for controlling cellular microenvironments
Elisa Figallo, Christopher Cannizzaro, Sharon Gerecht, Jason A. Burdick, Robert Langer, Nicola Elvassore and Gordana Vunjak-Novakovic, Lab Chip, 2007, 7, 710
DOI: 10.1039/b700063d


Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element
Andrew P. Golden and Joe Tien, Lab Chip, 2007, 7, 720
DOI: 10.1039/b618409j


Understanding microchannel culture: parameters involved in soluble factor signaling
Hongmei Yu, Caroline M. Alexander and David J. Beebe, Lab Chip, 2007, 7, 726
DOI: 10.1039/b618793e


Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes
Norbert Klauke, Godfrey Smith and Jonathan M. Cooper, Lab Chip, 2007, 7, 731
DOI: 10.1039/b706175g


High-density microfluidic arrays for cell cytotoxicity analysis
Zhanhui Wang, Min-Cheol Kim, Manuel Marquez and Todd Thorsen, Lab Chip, 2007, 7, 740
DOI: 10.1039/b618734j


Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices
Xuanhong Cheng, Yi-shao Liu, Daniel Irimia, Utkan Demirci, Liju Yang, Lee Zamir, William R. Rodríguez, Mehmet Toner and Rashid Bashir, Lab Chip, 2007, 7, 746
DOI: 10.1039/b705082h


A cell-laden microfluidic hydrogel
Yibo Ling, Jamie Rubin, Yuting Deng, Catherine Huang, Utkan Demirci, Jeffrey M. Karp and Ali Khademhosseini, Lab Chip, 2007, 7, 756
DOI: 10.1039/b615486g


A hydrogel-based microfluidic device for the studies of directed cell migration
Shing-Yi Cheng, Steven Heilman, Max Wasserman, Shivaun Archer, Michael L. Shuler and Mingming Wu, Lab Chip, 2007, 7, 763
DOI: 10.1039/b618463d


Efficient formation of uniform-sized embryoid bodies using a compartmentalized microchannel device
Yu-suke Torisawa, Bor-han Chueh, Dongeun Huh, Poornapriya Ramamurthy, Therese M. Roth, Kate F. Barald and Shuichi Takayama, Lab Chip, 2007, 7, 770
DOI: 10.1039/b618439a


A chip-based platform for the in vitro generation of tissues in three-dimensional organization
Eric Gottwald, Stefan Giselbrecht, Caroline Augspurger, Brigitte Lahni, Nina Dambrowsky, Roman Truckenmüller, Volker Piotter, Thomas Gietzelt, Oliver Wendt, Wilhelm Pfleging, Alex Welle, Alexandra Rolletschek, Anna M. Wobus and Karl-Friedrich Weibezahn, Lab Chip, 2007, 7, 777
DOI: 10.1039/b618488j


Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells
Jeffrey M. Karp, Judy Yeh, George Eng, Junji Fukuda, James Blumling, Kahp-Yang Suh, Jianjun Cheng, Alborz Mahdavi, Jeffrey Borenstein, Robert Langer and Ali Khademhosseini, Lab Chip, 2007, 7, 786
DOI: 10.1039/b705085m