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Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering
Contents list for Lab on a Chip, issue 6, 2007
Front cover
Lab Chip, 2007, 7, 653
DOI: 10.1039/b707371m
Contents and Chemical Technology
Lab Chip, 2007, 7, 655
DOI: 10.1039/b707372k
Highlight
Research Highlights
Lab Chip, 2007, 7, 663
DOI: 10.1039/b706143a
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Editorials
Special issue on Cell and Tissue Engineering in Microsystems
Lab Chip, 2007, 7, 666
DOI: 10.1039/b707014b
Sangeeta Bhatia and Christopher Chen consider the state-of-the-art in the field of Cell and Tissue Engineering in Microsystems and introduce the work contained in this special issue of Lab on a Chip.
Contributors to the Lab on a Chip Cell and Tissue Engineering in Microsystems special issue
Lab Chip, 2007, 7, 667
DOI: 10.1039/b707012h
Biographical profiles and photographs of special issue contributors.
Critical Review
Comparative study and improvement of current cell micro-patterning techniques
Jenny Fink, Manuel Théry, Ammar Azioune, Raphael Dupont, François Chatelain, Michel Bornens and Matthieu Piel,
Lab Chip, 2007, 7, 672
DOI: 10.1039/b618545b
Enhanced HTML article available
We discuss current micropatterning techniques for cell culture and describe a novel one-step UV-based protein patterning protocol for micron scale control of cell adhesion geometry.
Tutorial Review
A practical guide to microfluidic perfusion culture of adherent mammalian cells
Lily Kim, Yi-Chin Toh, Joel Voldman and Hanry Yu,
Lab Chip, 2007, 7, 681
DOI: 10.1039/b704602b Enhanced HTML article available
We present a practical guide to the robust operation of microfluidic perfusion culture systems so that they can be readily adopted for cell-based experimentation.
Papers
Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space
Sarah Tao, Conan Young, Stephen Redenti, Yiqin Zhang, Henry Klassen, Tejal Desai and Michael J. Young,
Lab Chip, 2007, 7, 695
DOI: 10.1039/b618583e Enhanced HTML article available
Micromachining-based ultra-thin film PMMA scaffolds are used to deliver retinal progenitor cells to the subretinal space of C57BL/6 mice for enhanced survival, migration, and differentiation.
Multiphase electropatterning of cells and biomaterials
Dirk R. Albrecht, Gregory H. Underhill, Avital Mendelson and Sangeeta N. Bhatia,
Lab Chip, 2007, 7, 702
DOI: 10.1039/b701306j Enhanced HTML article available
We fabricate multiphase tissues via dielectrophoretic micropatterning, in which cell-laden microgels are positioned within a second biomaterial, to avoid the need for a single material with both bioactive and structural properties.
Micro-bioreactor array for controlling cellular microenvironments
Elisa Figallo, Christopher Cannizzaro, Sharon Gerecht, Jason A. Burdick, Robert Langer, Nicola Elvassore and Gordana Vunjak-Novakovic,
Lab Chip, 2007, 7, 710
DOI: 10.1039/b700063d Enhanced HTML article available
Development of a micro-bioreactor array that combines the advantages of microarrays and bioreactors, and provides a means to study long-term growth and differentiation of hESCs under controlled conditions and in a multiarray setting.
Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element
Andrew P. Golden and Joe Tien,
Lab Chip, 2007, 7, 720
DOI: 10.1039/b618409j Enhanced HTML article available
A microfluidic collagen gel made using micromolded gelatin as a sacrificial template.
Understanding microchannel culture: parameters involved in soluble factor signaling
Hongmei Yu, Caroline M. Alexander and David J. Beebe,
Lab Chip, 2007, 7, 726
DOI: 10.1039/b618793e Enhanced HTML article available
Utilizing microchannel culture to examine basic culture parameters and their interactions using normal mammary gland epithelial cells (NMuMG).
Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes
Norbert Klauke, Godfrey Smith and Jonathan M. Cooper,
Lab Chip, 2007, 7, 731
DOI: 10.1039/b706175g Enhanced HTML article available
This paper describes a microfluidic environment that enables us to explore cell-to-cell signalling between longitudinally linked primary heart cells.
High-density microfluidic arrays for cell cytotoxicity analysis
Zhanhui Wang, Min-Cheol Kim, Manuel Marquez and Todd Thorsen,
Lab Chip, 2007, 7, 740
DOI: 10.1039/b618734j Enhanced HTML article available
High-density cytotoxicity screening is achieved within a 576 chamber microfluidic array, exposing rows of cells cultured on-chip to columns of toxins within defined chambers. Integrated microsieves in each chamber promote uniform cell seeding.
Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices
Xuanhong Cheng, Yi-shao Liu, Daniel Irimia, Utkan Demirci, Liju Yang, Lee Zamir, William R. Rodríguez, Mehmet Toner and Rashid Bashir,
Lab Chip, 2007, 7, 746
DOI: 10.1039/b705082h Enhanced HTML article available
We describe an electrical method for counting cells based on the measurement of changes in conductivity of the surrounding medium due to ions released from surface-immobilized cells within a microfluidic channel.
A cell-laden microfluidic hydrogel
Yibo Ling, Jamie Rubin, Yuting Deng, Catherine Huang, Utkan Demirci, Jeffrey M. Karp and Ali Khademhosseini,
Lab Chip, 2007, 7, 756
DOI: 10.1039/b615486g Enhanced HTML article available
A technique for fabricating microfluidic channels from cell-laden agarose hydrogels using standard soft lithographic techniques.
A hydrogel-based microfluidic device for the studies of directed cell migration
Shing-Yi Cheng, Steven Heilman, Max Wasserman, Shivaun Archer, Michael L. Shuler and Mingming Wu,
Lab Chip, 2007, 7, 763
DOI: 10.1039/b618463d Enhanced HTML article available
We have developed a hydrogel-based microchemotaxis device capable of generating a steady and long term linear chemical concentration gradient with no through flow in the center channel where cells reside. This device has been used to monitor successfully the chemotactic responses of suspension (Escherichia coli), and adherent (human leukemia) cells.
Efficient formation of uniform-sized embryoid bodies using a compartmentalized microchannel device
Yu-suke Torisawa, Bor-han Chueh, Dongeun Huh, Poornapriya Ramamurthy, Therese M. Roth, Kate F. Barald and Shuichi Takayama,
Lab Chip, 2007, 7, 770
DOI: 10.1039/b618439a Enhanced HTML article available
A microfluidic system is described for straightforward synchronized formation of uniform-sized EBs, the size of which can be controlled by changing the cross-sectional size of microchannels.
A chip-based platform for the in vitro generation of tissues in three-dimensional organization
Eric Gottwald, Stefan Giselbrecht, Caroline Augspurger, Brigitte Lahni, Nina Dambrowsky, Roman Truckenmüller, Volker Piotter, Thomas Gietzelt, Oliver Wendt, Wilhelm Pfleging, Alex Welle, Alexandra Rolletschek, Anna M. Wobus and Karl-Friedrich Weibezahn,
Lab Chip, 2007, 7, 777
DOI: 10.1039/b618488j Enhanced HTML article available
Hep G2 cells cultivated in a chip made of polycarbonate. Length, width and depth of one of the quadratic structures is 300 × 300 × 300 µm.
Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells
Jeffrey M. Karp, Judy Yeh, George Eng, Junji Fukuda, James Blumling, Kahp-Yang Suh, Jianjun Cheng, Alborz Mahdavi, Jeffrey Borenstein, Robert Langer and Ali Khademhosseini,
Lab Chip, 2007, 7, 786
DOI: 10.1039/b705085m Enhanced HTML article available
A method for fabrication of cell-repellant poly(ethylene glycol) microwells to form uniform size and shape embryoid bodies.
Back matter
Lab Chip, 2007, 7, 795
DOI: 10.1039/b707373a
Back cover
Lab Chip, 2007, 7, 799
DOI: 10.1039/b707374g
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