_tcm18-11405.gif )
Latest News
Chips & Tips: A method for rapid fabrication of microfluidic devices
30 June 2009
Rajan Kumar and colleagues explain how to rapidly fabricate microfluidic devices using double-sided tape and a T-shirt transfer press
Pioneers of Miniaturisation Prize 2009
25 June 2009
The third Pioneers of Miniaturisation prize will be awarded at µTAS 2009 Conference in Jeju, South Korea.
Printing artificial cells
19 June 2009
In a step towards cell mimics, an inkjet printer is being used to make lipid-coated balls containing proteins
Lab on a Chip video channel
Find out more about Lab on a Chip videos
Contents list for Lab on a Chip, issue 14, 2009
Front cover
Lab Chip, 2009, 9, 1973
DOI: 10.1039/b911748m
Inside front cover
Lab Chip, 2009, 9, 1974
DOI: 10.1039/b911749k
Contents and Chemical Technology
Lab Chip, 2009, 9, 1975
DOI: 10.1039/b911750b
Highlight
Research Highlights
Lab Chip, 2009, 9, 1985
DOI: 10.1039/b910873b
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Viewpoint
Cutting Edge: A novel lab-on-a-tube for multimodality neuromonitoring of patients with traumatic brain injury (TBI)
Justin Williams,
Lab Chip, 2009, 9, 1987
DOI: 10.1039/b906110j
Justin Williams provides a perspective on Li
s cutting edge paper describing a lab-on-a-tube for multimodal monitoring in traumatic brain injury.
Communications
A novel lab-on-a-tube for multimodality neuromonitoring of patients with traumatic brain injury (TBI)
Chunyan Li, Pei-Ming Wu, WooSeok Jung, Chong H. Ahn, Lori A. Shutter and Raj K. Narayan,
Lab Chip, 2009, 9, 1988
DOI: 10.1039/b900651f
A novel lab-on-a-tube integrated with spirally-rolled pressure, temperature, oxygen and glucose microsensors is described for multimodal neuromonitoring of patients with traumatic brain injury.
Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells
Ryota Kojima, Keitaro Yoshimoto, Emiko Takahashi, Masahiro Ichino, Hirotoshi Miyoshi and Yukio Nagasaki,
Lab Chip, 2009, 9, 1991
DOI: 10.1039/b903388b
We have successfully constructed a spheroid array of fetal mouse liver cells (FMLCs) on a PEG-gel micropatterned surface. Interestingly, the activity was significantly enhanced by co-culture with nonparenchymal liver cells.
Laminar flow used as 
liquid etch mask
in wet chemical etching to generate glass microstructures with an improved aspect ratio
Xuan Mu, Qionglin Liang, Ping Hu, Kangning Ren, Yiming Wang and Guoan Luo,
Lab Chip, 2009, 9, 1994
DOI: 10.1039/b904769g
Laminar flow is employed in this method as to mask the flow of an etchant and is termed as liquid etch mask. Consequently this mask has the physical properties of a liquid. In this work, the aspect ratio of the glass channel could be improved to 
1 while in an inexpensive and convenient manner.
Papers
Dynamic bioprocessing and microfluidic transport control with smart magnetic nanoparticles in laminar-flow devices
James J. Lai, Kjell E. Nelson, Michael A. Nash, Allan S. Hoffman, Paul Yager and Patrick S. Stayton,
Lab Chip, 2009, 9, 1997
DOI: 10.1039/b817754f
A new strategy is described for exploiting the sharply reversible change in size and magnetophoretic mobility of smart magnetic nanoparticles (mNPs) to perform bioseparation and target isolation under continuous flow processing conditions.
Inkjet formation of unilamellar lipid vesicles for cell-like encapsulation
Jeanne C. Stachowiak, David L. Richmond, Thomas H. Li, Françoise Brochard-Wyart and Daniel A. Fletcher,
Lab Chip, 2009, 9, 2003
DOI: 10.1039/b904984c
Monodisperse, unilamellar lipid vesicles of unrestricted content were formed at rates up to 200 Hz using inkjet printing, where a microfluidic jet deforms a planar lipid membrane. Actin network polymerization is initiated upon vesicle formation to demonstrate the control of cell-like encapsulated reactions.
DNA-barcode directed capture and electrochemical metabolic analysis of single mammalian cells on a microelectrode array
Erik S. Douglas, Sonny C. Hsiao, Hiroaki Onoe, Carolyn R. Bertozzi, Matthew B. Francis and Richard A. Mathies,
Lab Chip, 2009, 9, 2010
DOI: 10.1039/b821690h
Microdevice for the DNA-barcode directed capture of single cells on individual elements of an array of pH-sensitive microelectrodes and their differential metabolic analysis.
Self-powered microfluidic chips for multiplexed protein assays from whole blood
Lidong Qin, Ophir Vermesh, Qihui Shi and James R. Heath,
Lab Chip, 2009, 9, 2016
DOI: 10.1039/b821247c
A plug-and-play platform performs high throughput, accurate, multiplexed blood diagnostic measurements.
A microfluidic platform to synthesise a G-quadruplex binding ligand
N. M. Smith, B. Corry, K. Swaminathan Iyer, M. Norret and C. L. Raston,
Lab Chip, 2009, 9, 2021
DOI: 10.1039/b902986a
A novel approach to the synthesis of a dimethylamino functionalised 4
-aryl-2,6-bis(4-aminophenyl)pyridine has been developed, involving dynamic thin films, overcoming a series of competing reactions, effectively controlling chemical reactivity and selectivity.
A microfluidic 3D hepatocyte chip for drug toxicity testing
Yi-Chin Toh, Teck Chuan Lim, Dean Tai, Guangfa Xiao, Danny van Noort and Hanry Yu,
Lab Chip, 2009, 9, 2026
DOI: 10.1039/b900912d
We have developed a microfluidic 3D hepatocyte chip (3D HepaTox Chip) for in vitro drug toxicity testing to predict in vivo drug hepatotoxicity.
Three-dimensional micro-electrode array for recording dissociated neuronal cultures
Katherine Musick, David Khatami and Bruce C. Wheeler,
Lab Chip, 2009, 9, 2036
DOI: 10.1039/b820596e
A three-dimensional micro-electrode array for in vitro use has been designed, fabricated, packaged, and characterized. Successful function has been demonstrated with spontaneous and evoked signals from a dissociated neuronal culture.
Study of cellular behaviors on concave and convex microstructures fabricated from elastic PDMS membranes
Joong Yull Park, Dae Ho Lee, Eun Joong Lee and Sang-Hoon Lee,
Lab Chip, 2009, 9, 2043
DOI: 10.1039/b820955c
We successfully fabricated concave and convex microstructures, and used these microstructures to study the responses of cultured fibroblast cells (left) and human mesenchymal stem cells (right). These cells clearly sensed the three-dimensional microscale curvature and actively escaped from concave patterns.
Tunable Liquid Gradient Refractive Index (L-GRIN) lens with two degrees of freedom
Xiaole Mao, Sz-Chin Steven Lin, Michael Ian Lapsley, Jinjie Shi, Bala Krishna Juluri and Tony Jun Huang,
Lab Chip, 2009, 9, 2050
DOI: 10.1039/b822982a
The Liquid Gradient Refractive Index (L-GRIN) lens enables flexible on-chip manipulation of the light with two degrees of freedom, including the variable focusing (translation mode) and change of the focused light direction (swing mode).
Multipoint viscosity measurements in microfluidic channels using optical tweezers
Stephen Keen, Alison Yao, Jonathan Leach, Roberto Di Leonardo, Chris Saunter, Gordon Love, Jonathan Cooper and Miles Padgett,
Lab Chip, 2009, 9, 2059
DOI: 10.1039/b900934e
We demonstrate the technique of multipoint viscosity measurements and describe the use of a high-speed camera to measure the residual motion of particles trapped in holographic optical tweezers, enabling us to calculate the fluid viscosity at multiple points across the field-of-view of the microscope within a microfluidic system.
Free jet micromixer to study fast chemical reactions by small angle X-ray scattering
Benedetta Marmiroli, Gianluca Grenci, Fernando Cacho-Nerin, Barbara Sartori, Enrico Ferrari, Peter Laggner, Luca Businaro and Heinz Amenitsch,
Lab Chip, 2009, 9, 2063
DOI: 10.1039/b904296b
We designed, fabricated and tested a continuous flow micromixer with a free jet to study the nanoparticle formation within the jet with small angle X-ray scattering (time resolution: 75 µs).
Passive flow-rate regulators using pressure-dependent autonomous deflection of parallel membrane valves
Il Doh and Young-Ho Cho,
Lab Chip, 2009, 9, 2070
DOI: 10.1039/b821524c
Passive flow-rate regulators using an autonomous deflection of parallel membrane valves, capable of maintaining a constant flow-rate at varying inlet pressure supplied by micropumps.
Demonstration of an integrated electroactive polymer actuator on a microfluidic electrophoresis device
Alexander K. Price, Kristen M. Anderson and Christopher T. Culbertson,
Lab Chip, 2009, 9, 2076
DOI: 10.1039/b823465e
Miniature actuators based upon dielectric elastomers can be easily integrated into a microfluidic device and used to manipulate fluid flows at intersections.
A three-phase microfluidic chip for rapid sample clean-up of alkaloids from plant extracts
Kishore K. R. Tetala, Jan W. Swarts, Bo Chen, Anja E. M. Janssen and Teris A. van Beek,
Lab Chip, 2009, 9, 2085
DOI: 10.1039/b822106e
A three-phase microchip was developed for the rapid and efficient small-scale purification of alkaloids from plant extracts.
Osmotically driven flows in microchannels separated by a semipermeable membrane
Kċre Hartvig Jensen, Jinkee Lee, Tomas Bohr and Henrik Bruus,
Lab Chip, 2009, 9, 2093
DOI: 10.1039/b818937d
We have studied osmotically driven, transient flows in 200 µm wide and 50200 µm deep microchannels separated by a semipermeable membrane integrated in a microfluidic PMMA chip.
Back matter
Lab Chip, 2009, 9, 2100
DOI: 10.1039/b911751m
Back cover
Lab Chip, 2009, 9, 2103
DOI: 10.1039/b911752k
RSS feed
