Issue 12, 2006

Genome-scale analysis has been extended from gene expression profiling to parallel cell-based functional profiling, allowing the characterization of gene function and small molecule actions in yeast and in mammalian cells.
DOI: 10.1039/B609384A

Issue 11, 2006

Acetylcholine receptors in the cell membrane provide an example of the ways in which ion channel proteins mediate the passage of ions to initiate a range of intracellular responses.
DOI: 10.1039/B610062G

Issue 10, 2006

Structure of cytochrome P450
DOI: 10.1039/B607001A

Issue 9, 2006

The data generated from protein fingerprints (middle) with an O-helical peptide microarray (under) were analyzed using several statistical methods (upper) to discriminate target proteins.
DOI: 10.1039/B608875A

Issue 8, 2006

Myriaporone (red) represents just one hemisphere of the macrolide ribosome inhibitor, tedanolide (violet/red). Nevertheless, it retains most of its activity.
DOI: 10.1039/B602936A

Issue 6-7, 2006

The release of ATP from diabetic erythrocytes in resistance vessels: a recognized nitric oxide stimulus affected by oxidative stress.
DOI: 10.1039/B604362N

Issue 5, 2006

MHC class I-presented antigenic peptides can be chemically transformed to be equipped, in their central part, with small natural molecules, such as the Hyrtios erectus spongederived (+)-puupehenone, and still be recognized by receptors of CD8+ T-cells for induction of immune responses.
DOI: 10.1039/B518044A

Issue 3-4, 2006

On-line detection of the binding of ions and peptides to surface-attached calmodulin is reported, resulting in a semiquantitative detection of a protein conformational change.
DOI: 10.1039/B600186F

Issue 2, 2006

The marked changes in the fluorescence of base discriminating fluorescent probes play a key role in a facile homogeneous SNP typing assay.
DOI: 10.1039/B515923G

Issue 2, 2006 (Inside)

Ratiometric fluorescent labeling technology was developed by utilizing a field-sensitive probe (dansyl-NTA-Ni2+ complex) and its corresponding tag (Trp-His-tag), in which RNase S' was used as a model protein.
DOI: 10.1039/B600324A

Issue 1, 2006

The image displays a novel nanodroplet microarray platform to rapidly profile and discover enzyme inhibitors.
DOI: 10.1039/B513935J