Issue 12, 2007

Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism.

Issue 11, 2007

A model of human FKBP12 mutated in silico to resemble maize FKBP12 at the rapamycin binding region. The green structure is the rapamycin molecule inserted at the binding cavity of FKBP12. Red represents regions of negative electrostatic potential and blue represents positive potentials.

Issue 10, 2007

Optical switches and triggers for the manipulation of ion channels and pores.

Issue 9, 2007

Transcript/proteomic analysis of wild-type and glucose sensing mutant Baker's yeast (Saccharomyces cerevisiae) strains suggest carbon source sensing contributes to pseudohyphal differentiation as part of glycolysis. This novel transduction pathway may help elucidate this complex multi-component pathway which is used as a model system for understanding aspects of pathogen virulence and invasive behavior. 

Issue 8, 2007

A mosaic of artificially colored images that represent a new technical advance in controlled spatial and temporal expression of genes on a developing butterfly wing.

Issue 7, 2007

Systems biology of embryonic patterning in Xenopus. The cover shows a frog embryo stained for the expression of dorsal (top) and ventral (bottom) genes. The dorsal gene is Chordin, an inhibitor of Bone Morphogenetic proteins (BMPs). The ventral gene is Sizzled, an inhibitor of Tolloid metalloproteinases that digest Chordin. The circular structure is the blastopore, which later on will close to form the anus.

Issue 6, 2007

Novel tRNA Aminoacylation Reactions.

Issue 5, 2007

Antimicrobial ribonucleases. Eosinophil Cationic Protein (RNase 3) action on Escherichia coli cells, as visualized by scanning electron microscopy.

Issue 4, 2007

The prototypical cyclotide kalata B1 is shown superimposed upon the sweet violet (Viola odorata), a source of this peptide. Cyclotides are topologically unique plant defence proteins that have a cyclic backbone and knotted arrangement of disulfide bonds, that contribute to their remarkable stability.
DOI: 10.1039/B616856F

Issue 3, 2007

Fish 'n' Chips: the use of microarrays for aquatic toxicology.
DOI: 10.1039/B612802P

Issue 2, 2007

Single-molecule studies of complex systems: the replisome
DOI: 10.1039/B612545J

Issue 1, 2007

Controlling influenza virus replication by inhibiting its proton channel.
DOI: 10.1039/B611613M