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Previous news from Metallomics
Contents list for Metallomics, issue 6, 2009
Front cover
Metallomics, 2009, 1, 445
DOI: 10.1039/b921981c
Contents and Highlights in Chemical Biology
Metallomics, 2009, 1, 447
DOI: 10.1039/b921982j
Editorial
Metallomics scope
Metallomics, 2009, 1, 457
DOI: 10.1039/b921988a
Critical Review
Recent developments in ruthenium anticancer drugs
Aviva Levina, Anannya Mitra and Peter A. Lay,
Metallomics, 2009, 1, 458
DOI: 10.1039/b904071d
Enhanced HTML article available
Generalised pathways of action of Ru(III/II) anticancer complexes (LnRu–X in the Scheme, where L are the tightly bound ligands and X is the leaving group), based on their partial hydrolysis and competitive interactions with various types of biomolecules (see Scheme), are proposed for the first time.
Papers
Beryllium uptake and related biological effects studied in THP-1 differentiated macrophages
Jian Ding, Lin Lin, Wei Hang and Xiaomei Yan,
Metallomics, 2009, 1, 471
DOI: 10.1039/b913265a Enhanced HTML article available
Cellular beryllium content measurement indicated that the uptake of particulate BeO was much more significant than that of soluble BeSO4, suggesting the major cellular uptake pathway is phagocytosis. However, incorporated beryllium has negligible cytotoxicity to THP-1 macrophages.
Incorporation of excess gadolinium into human bone from medical contrast agents
Thomas H. Darrah, Jennifer J. Prutsman-Pfeiffer, Robert J. Poreda, M. Ellen Campbell, Peter V. Hauschka and Robyn E. Hannigan,
Metallomics, 2009, 1, 479
DOI: 10.1039/b905145g Enhanced HTML article available
This research documents the incorporation and retention of gadolinium in bone tissue of patients exposed to chelated Gd during contrast MRI, and investigates its potential effects on health, on bone and the impacts of bone pathology on metal incorporation.
The plant metallothionein 2 from Cicer arietinum forms a single metal–thiolate cluster
Xiaoqiong Wan and Eva Freisinger,
Metallomics, 2009, 1, 489
DOI: 10.1039/b906428a Enhanced HTML article available
The first spectroscopic characterization of metallothionein 2 from chickpea reveals its metal-binding ability for divalent metal ions and suggests the formation of a single metal–thiolate cluster.
Denaturing and non-denaturing microsolution isoelectric focussing to mine the metalloproteome
Barbara Pioselli, Caroline Munro, Andrea Raab, Christian L. Deitrich, Kriangsak Songsrirote, Jörg Feldmann and Jane Thomas-Oates,
Metallomics, 2009, 1, 501
DOI: 10.1039/b903607e Enhanced HTML article available
Denaturing and non-denaturing conditions for solution isoelectric focussing of metalloproteins have been developed and applied to a complex metalloproteome.
Pseudo-halide derivatives of titanocene Y: synthesis and cytotoxicity studies
James Claffey, Anthony Deally, Brendan Gleeson, Megan Hogan, Luis Miguel Menéndez Méndez, Helge Müller-Bunz, Siddappa Patil, Denise Wallis and Matthias Tacke,
Metallomics, 2009, 1, 511
DOI: 10.1039/b911753a Enhanced HTML article available
Four pseudo-halide substituted analogues of Titanocene Y were synthesised and their cytotoxicity tests on pig LLC-PK cells and a structural discussion of two derivatives are reported.
The metallomics approach: use of Fe(II) and Cu(II) footprinting to examine metal binding sites on serum albumins
Michael R. Duff, Jr.,Challa V. Kumar,
Metallomics, 2009, 1, 518
DOI: 10.1039/b910253a Enhanced HTML article available
Metal binding to serum albumins is examined by oxidative protein-cleavage chemistry, and relative affinities of multiple metal ions to particular sites on these proteins were identified using a fast and reliable chemical footprinting approach.
Back matter
Metallomics, 2009, 1, 524
DOI: 10.1039/b921998f
Back cover
Metallomics, 2009, 1, 527
DOI: 10.1039/b921983h
