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The international home of synthetic, physical and biomolecular organic chemistry.
Cover Gallery
SN1 and SN2 transition states for the reaction of a bicyclic sulfonium ion based on the MTX sugar from Mycobacterium tuberculosis (background image - supplied by Centers for Disease Control and Prevention (CDC))
DOI: 10.1039/B914417J
A cationic rhodium(I) complex catalyzes carboxylative cyclizations of 1,6-diynes to cyclic dienyl carboxylates in high yields with high chemo-, regio-, and stereoselectivities under mild reaction conditions. (The background picture is the sunset of lake Saroma, the biggest lake in Hokkaido, Japan.)
DOI: 10.1039/B922538M
Fingerprints, iris-scans, barcodes, or the data of chemosensors: pattern recognition techniques can be the key for a successful analysis.
DOI: 10.1039/b912400d
The cover image depicts Battery Point Lighthouse in Crescent City, CA (photograph by Rich G. Carter) with chemical graphics of amphidinolides C / F and the synthesized C7-C20 subunit superimposed in the foreground.
DOI: 10.1039/b921542p
The effects of structural modifications on the difference in free energy for the equilibrium processes in switchable mechanically interlocked molecules can be predicted by considering, firstly, the interactions present in their precursor pseudorotaxanes. Artwork by Mark A. Olson.
DOI: 10.1039/b911874h
Inspired by Salvator Dali's painting "jaune d'oeuf soleil" this artwork, representing the Salagou Lake near Montpellier, asks the question whether boron might have played a role in the pre-RNA world. We describe here the synthesis of the four 2'-deoxyborononucleotide analogues of natural nucleotide monophosphates and demonstrate that these analogues form a new borono-based internucleosidic linkage with uridine
DOI: 10.1039/b920437g
The image illustrates the click conjugation of an unprotected integrin binding peptide onto a FITC-labelled cyclic template in multiple copies. Coupling partners, resulting conjugates, and a target receptor are drawn as space filling models.
DOI: 10.1039/b908261a
The picture is of Yunnan Garden, which sits in front of the Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences building at Nanyang Technological University, Singapore.
DOI: 10.1039/b919316m
Replacement of the third strand of a triple-helical DNA by NF-kB, p50/p65, results in a decreased FRET and represents a new assay principle for DNA-binding proteins
DOI: 10.1039/b906447h
A heterodimeric fluorescent tool with strong excitation-emission peak to successfully analyze beta-amyloid plaques in brain samples from mice and humans
DOI: 10.1039/b918145h
A representation of the global minimum conformation of 13,19-didesmethyl spirolide C along with its 1H-NMR spectrum, and of the toxic dinoflagellate Alexandrium ostenfeldii ( the producing organism of the marine fast-acting spirolide toxins).
DOI: 10.1039/B907649B
The four structures in the picture are nor-carotenoid, peridinin, which is a representative auxiliary light harvesting pigment for photosynthesis in the sea, and its analogues. Another structure represents the PC complex which consists of eight peridinin and two chlorophyl a. Glittering leaves at the backside of the structures represents photosynthesis.
DOI: 10.1039/b916351b
The haemagglutinin noose epitope (HNE) of the H-protein of measles virus and the mouse monoclonal antibodies specifically binding this epitope acted as tools to develop a novel construct of the HNE-peptide bound to a bile-acid scaffold. The H-protein (pbd code 2ZB6) illustration was performed with Pymol.
DOI: 10.1039/B907395G
Reduction of disulfides within antibodies and cysteine-based fluorescent tagging with a water-soluble maleimide reagent allows for a convenient way to sort cells and label proteins
DOI: 10.1039/b915537f
The extent of intramolecular Förster energy transfer (FRET) was controlled by varying the core substituents of only one deck in rigid NDI cyclophanes.
DOI: 10.1039/b905945h
Continuous intramolecular hydrogen bonds induce linear precursors to adopt matched U-shaped conformations, which remarkably promote the formation of macrocyclic architectures through the click chemistry
DOI: 10.1039/b914227b
Electron micrograph provided by Dr W. Barkhuff (Vermont) of two T. gondii parasites. The thimble-shaped conoid is extended in one (left) and retracted in the other. Conoidin A (inset) inhibits conoid extension and was found to bind covalently to the protein shown (peroxiredoxin II).
DOI: 10.1039/b901735f
We established a unique synthetic route to coronatine employing an exo-selective Diels-Alder reaction as a key step. A remarkable difference in stomatal opening activity between the enantiomers of coronatine was observed.
DOI: 10.1039/b913076b
Nucleoside analogues are highly important in biochemistry, biology and medicine. Modified guanosine nucleosides are now easily accessible via novel O6-(benzotriazol-1-yl) derivatives.
DOI: 10.1039/b905298D
Orexin-B, a 28-residue neuropeptide associated with food craving and wakefulness, was efficiently synthesized by solution phase racemisation-free O-acyl isopeptide segment condensation.
DOI: 10.1039/b911917p
Asymmetric synthesis of the tropane alkaloid, (+)-physoperuvine from Physalis peruviana Linne (background) via a one-pot tandem rearrangement and ring closing metathesis reaction. Background photograph reproduced with permission from Christine Ashe.
DOI: 10.1039/B907341H
Jellyfish-like polycationic amphiphilic cyclodextrins assembled by click chemistry efficiently compact plasmid DNA, forming nanometric complexes (CDplexes) with remarkable gene delivery capabilities.
DOI: 10.1039/b910929n
Irish chirality old and new: The spiral background is taken from a 5000 year old Irish design found at the entrance to a Neolithic passage tomb at Newgrange, Ireland. The entrance to the tomb is shown in the inset image.
DOI: 10.1039/b900741e
Calix[6]arenes shaped into conic funnels through biomimetic coordination chemistry or self-assembly are remarkable receptors for neutral guests. Their versatility allows tuning and switching behaviours.
DOI: 10.1039/b909943n
Mimicry is a fundamental concept for the chemist in designing useful peptidomimetics as well as for certain animals, like pygmy seahorses, in defending their own life.
DOI: 10.1039/b901718f
The hydrophobic surface calculated for the active site of b-glucosidase A is depicted as the background image for aldol-based synthesis of pyrrolidine homoazasugars and polyhydroxylated prolines.
DOI: 10.1039/b909028m
IMes-Pd(dmba)Cl is a highly active and practical Heck- Mizoroki precatalyst developed in Singapore, symbolized by the Merlion waterfront landmark.
DOI: 10.1039/b821892g
A diatom, Chaetoseros calcitrans, contains unique chlorophylls-c having a conjugated acrylate residue at the 17-position. The residue functions to expand the absorption region at around 400-500 nm for photosynthesis.
DOI: 10.1039/b908082c
The fluorescence of a dicarboazolylurea-based anion receptor is selectively quenched upon addition of benzoate anions to the receptor in DMSO-d6/water solution.
DOI: 10.1039/B900178F
As a metaphor for the various synthetic approaches one can use to assemble a desired target structure, the cover shows pictures of six different entry ways.
DOI: 10.1039/b906533b
The photophysical properties of polyfluorosubstituted pyrazolines were predicted based on free energy relationships with Hammett constants derived from theoretical electrostatic potentials at carbon nuclei.
DOI: 10.1039/B821042J
The intramolecular disulfide bond of human relaxin-3, an insulin-like peptide having potential applications in the treatment of obesity, was replaced with the physiologically stable dicarba bond.
DOI: 10.1039/b905508h
Desired structures would be constructed by the photoreaction using anthracene-modified oligonucleotides as building blocks
DOI: 10.1039/b821869b
The image illustrates the process of imaging caspase-3, showing the fluorination of the starting mesylate, binding to the enzyme's active site and a representative PET image
DOI: 10.1039/b904482p
Clay mineral exercises its asymmetric power to synthesize highly enantioenriched organic compounds in combination with asymmetric autocatalysis
DOI: 10.1039/b823282b
A fluorescent metallacrown complex can be used as a turn-on chemosensor for the pharmacologically important lithium ion
DOI: 10.1039/b903493p
Synthesis of hydrophilic conjugated porphyrin dimers for one-photon and two-photon photodynamic therapy at NIR wavelengths
DOI: 10.1039/b814789b
Synthesis and Biological Activity of the (25R)-Cholesten-26-oic Acids - Ligands for the Hormonal Receptor DAF-12 in Caenorhabditis elegans
DOI: 10.1039/b902411p
New thermolytic carbamoyl groups for the protection of nucleobases
DOI: 10.1039/b816831h
First Y-type actinomycins from Streptomyces with divergent structure-activity relationships for antibacterial and cytotoxic properties
DOI: 10.1039/b815689a
Synthesis of the originally proposed structures of elatenyne and an enyne from Laurencia majuscula
DOI: 10.1039/b814953D
Switchable electrostatic interactions between gold nanoparticles and coiled coil peptides direct colloid assembly
DOI: 10.1039/b821218j
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