Molecular BioSystems is an interdisciplinary journal publishing novel and significant research that is emerging at the interface between chemistry and biology. The journal is intended as a forum for high quality accounts of the research and development at the interface between chemistry and the -omic sciences and systems biology, in particular research concerned with cellular processes, metabolism, proteomics and genomics, systems biology, drug discovery, biomaterials, and all techniques relevant to these subject areas.

Please bear in mind that the readership of Molecular BioSystems is very wide-ranging. It is not expected therefore that readers will be up-to-date with all of the work published in these article types. It is therefore essential that the article is clearly written, up-to-date, and easily comprehensible to the non-specialist.

Opinions are intended to provide a personal, often speculative, viewpoint or hypothesis on a topic of current interest to the Molecular BioSystems community. Provided that they are not defamatory to the work of others they can be controversial and stimulate counter-opinion.

1. How would you rate this paper? *
   
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2. Does the article provide explanation and introduction at a level intelligible to the non-specialist? *
   
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3. Are the references up-to-date and accessible, and have all key references been cited? *
   
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   Please give details in your comments of any citations that have been omitted.

   
   

4. Could any material be transferred to the RSC's Electronic Supplementary Information area? *
   
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   Please give details in your comments.

   
   

5. Is the article's length commensurate with its content? (Please consider any relevant page limits when answering) *
   
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   If the article is too long, please include in your comments recommendations for deleting text, tables or illustrations.

   
   

6. What is your recommendation? *
   
   Accept - unchanged
   Accept - with minor revisions
   Reconsider - after major revisions
   Reject
   
   Your recommendation cannot be used unless justification is provided. Please support your recommendation in your comments.

   
   

If you recommend acceptance you must provide details to support this decision and you should outline any revisions (which should be achievable within 10 days) and indicate any additional experimental evidence required to support the results (e.g. as Electronic Supplementary Information).

If you recommend rejection you must provide details to support this decision. If you feel that work may be suitable for publication elsewhere please indicate the most appropriate journal and format.

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