Molecular muscle machines bulk up

French researchers have made the longest molecular machines that can be shrunk on demand in a collective motion that emulate muscle fibres.1Nicolas Giuseppone from the University of Strasbourg and his teammates linked together strings of around 3000 macromolecular daisy-chain rotaxane monomers that contract under basic conditions. The resulting polymer went from 15.8 µm to 9.4 µm, movement in the range of that produced by sarcomere proteins, the basic building blocks of muscle. That amplifies a single daisy-chain rotaxane’s contraction by nearly four orders of magnitude, Giuseppone tells Chemistry World. ‘This is a result long expected by the community, but it is the first example,’ he says. ‘We can expect numerous applications in nanotechnologies for the design of artificial muscles, micro-robots or developing new materials incorporating nanomachines endowed with novel multi-scale mechanical properties.’

rotaxane muscles

Shrinkable daisy-chain rotaxanes can be coupled together to amplify their motion © Wiley

Daisy-chain rotaxanes feature two crown ether rings with linear chains extending from them, each chain then threads through the middle of the other ring. Under acidic conditions, the ring closely binds a protonated amine on the chain threaded through it but when the amines are deprotonated, the rings travel down the chains towards a permanently positively charged group and stopper, shortening the distance between the chain ends. Previously researchers made polymers that could sum that motion by coupling neighbouring rotaxanes chain-ends using azide–alkyne cycloaddition ‘click chemistry’. However, these chains featured 22 monomers at most and were poorly soluble.

Giuseppone’s team therefore turned away from covalent linkages, instead joining monomers through metal co-ordination. They attached three pyridine rings to the end of each chain, so that two such terpyridinyl terminal groups would come together to tightly grasp Fe2+ ions the researchers introduced. ‘This kind of association was known, but only to connect simple monomers,’ Giuseppone says. Bringing it to molecular machines took a synthetic ‘tour de force’, he adds, as making the monomers was a 13-step synthesis. The resulting polymers are also soluble, allowing co-author Erich Buhler’s team at University of Paris Diderot—Paris VII to study their structures in detail with neutron scattering.

Northwestern University’s Fraser Stoddart in the US says he welcomes this work as a step towards overcoming the barriers to delivering a new generation of complex artificial molecular machines that he outlined earlier this year.2 He says it brings the field ‘closer to the dream of materials that employ concerted motions of countless molecular machines to deliver work against a load on the macroscopic scale, as do the muscles in our own bodies.’


Related Content

Rotaxane mimics ribosome to spin out peptides

10 January 2013 Research

news image

Bio-inspired molecular machine can piece together three amino acids

Welcome to the machine

6 January 2010 Feature

news image

Molecular machines have promised so much but are they more whimsical than technical? Philip Ball investigates

Most Read

Flushing advice is flawed

24 August 2015 Research

news image

Protocols to restore contaminated water supplies are not based on science

Simple chemistry saving thousands of gold miners from mercury poisoning

25 August 2015 News and Analysis

news image

Basic apparatus is cutting mercury pollution and helping Indonesian miners go for gold

Most Commented

Paper device tracks fracking pollution

21 August 2015 Research

news image

Cheap and simple bromide sensor warns if water has been contaminated with fracking fluid

New drug treatment for alcoholism shows promise in animal studies

24 August 2015 Research

news image

Compounds that target a receptor in the brain appear less addictive with fewer negative side-effects than existing drugs