29 July 2013 Research
That’s a lot of boron!
Real-time biodistribution patterns of the COSAN derivatives
Researchers in Spain have come up with a way to track the biodistribution of a boron cluster complex used to prepare boron-carrier drugs for a prospectvie cancer treatment called boron neutron capture therapy (BNCT).
Drugs based on the boron cluster complex COSAN (cobaltabisdicarbollide) exploit the over-expression of membrane receptors in cancer cells to deliver therapeutic levels of 10B across the membrane. Although 10B is a stable isotope, when a beam of low-energy neutrons is applied to the cell, 10B captures a neutron and subsequently decays, releasing a high-energy α-particle and destroying the cell.
Radioiodination will make it possible to track the compounds
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