RSC - Advancing the Chemical Sciences


Chemistry World

 

Nanoparticles give cancer drug a boost


19 February 2009

US scientists have taken a novel step towards fighting the reoccurrence of lung cancer, using drug delivering nanoparticles. Their leak-free polymer nanoparticles, which have been tested in vivo, only open and deliver their cargo once inside the acidic environment of a cell.

The multidisciplinary team led by Mark Grinstaff of Boston University and Yolonda Colson of Brigham and Women's Hospital, also in Boston, have designed nanoparticles to carry the anti-cancer drug paclitaxel (Taxol) and tested their efficiency on mice. The nanoparticles switch behaviour from hydrophobic to hydrophilic upon entering a cell, triggering the release of the drug.  

Expanded hydrogel nanoparticle
The nanoparticles swell (above) in an acidic environment, triggering the release of the drug they are carrying

© JACS

'What is unique about these particles, and differentiates them from other types of nanoparticles,' explains Grinstaff, 'is that when they enter a mildly acidic environment - pH 4 that you find in the endosome - they swell and that swelling results in water entering the system and the drug being released.' The nanoparticles swell from 100 nanometres to more like 1000 nanometres and the final particle is a very loose structure that is more like a hydrogel-type polymer structure, he adds.

'Another thing that is unique about these is that the drug really does release only in response to the pH change,' he adds. 'Most drug delivery systems are very leaky.'

Kenneth Suslick, University of Illinois at Urbana-Champaign, US, an expert in nanoparticles, says that 'this is a particularly exciting application. The use of a pH controlled swelling of a polymeric material to release a drug is a very clever innovation. As far as I know, for drug delivery, this is the first of its kind.'

Moving into the body

Lung cancer kills 1.3 million people worldwide annually. After a tumour has been surgically removed, there is a 30 per cent chance that the cancer will return within five years, says Grinstaff, because of the residual cancer cells left in the area from which the tumour was removed. Grinstaff envisages that the nanoparticles will be applied to this problem area, on the operating table, immediately after the tumour has been removed.

The team was able to prove that the paclitaxel-carrying nanoparticles perform better than paclitaxel alone using a mouse model. 'In this model we made an incision in the back of a mouse and injected cancer cells - mimicking the residual cancer cells that are left at the site. Then we injected the nanoparticles with the drug and found that no tumour would grow,' Grinstaff said. If you do not use nanoparticles, and just inject the drug by itself, the cancer cells still multiply, he adds. 'The reason is that the drug by itself diffuses away from the site too fast for it to be taken up by the cancer cells. So you need a delivery system that will stay around long enough so that the drug can be taken up by the cancer cells.' 

'Grinstaff has chosen a particularly important drug application,' says Suslicks. 'Currently Taxol is administered over 24 hours using a slow intravenous drip, as it is exceedingly water insoluble and has to be administered in a solution that the body can tolerate. And because of its insolubility that ends up being a large volume. Being able to encapsulate the drug and then release it in situ is a particularly desirable goal.'

Having proved its viability as a drug carrier, Grinstaff says that the 'major goals for 2009 are to carryout a full toxicology screen on the polymer and then a large animal safety study.'

Nina Notman

 

Interesting story? Spread the word using the 'tools' menu on the left.

References

Aaron P. Griset et al, J. Am. Chem. Soc., 2009, DOI: 10.1021/ja807416t

Also of interest

DNA-conjugated polymer hydrogel

Lights on for drug delivery

17 December 2008

Chinese scientists have developed fluorescent drug delivery vehicles that can be used to monitor drug release


Micelle releasing contents

Drug delivery on target

17 November 2008

A peptide found in tumour cells can trigger the release of drugs from a novel nanocarrier, claim South Korean scientists


Drug delivery device for the eye

An eye for drug delivery

09 June 2008

Patients with glaucoma and related eye diseases could soon be treated with a refillable drug delivery device - replacing the need for injections into the eyeball.


Related Links

Link icon Comment on this story at the Chemistry World blog
Read other posts and join in the discussion


External links will open in a new browser window