MOF magnets deliver drugs
04 February 2011
German scientists have encapsulated nanomagnets inside metal organic frameworks (MOFs). The MOF magnets can be filled with a drug, which is released when a magnetic field is applied.
Stefan Kaskel from the Technical University of Dresden and colleagues made the MOF magnets by integrating superparamagnetic iron oxide particles into carboxylate MOFs. 'Carboxylate molecules stabilise and activate the nanoparticles,' explains team member Martin Lohe.
The group then loaded their MOF with ibuprofen and found that they were able to trigger and control its release by simply applying an external magnetic field. The magnetic field heats the magnets in the MOF, which causes the load to burst from the framework.
Superparamagnetic functionalisation of MOFs enables magnetic heating to trigger drug delivery
MOFs in which the frameworks themselves are magnetic have been made before, but they are not easy to manipulate. Kaskel's embedded MOF magnets, however, can easily be manipulated from the outside. Magnetic fields can penetrate human skin, and magnetic triggers that could be used to release the drugs are already available on the market. However, before the MOF magnets can be used in the human body, toxicity tests will need to be done.
'An enhanced sustainability of industrial and medical processes is crucial for our future,' says Lohe. 'Magnetically functionalised MOFs could be a small building block on this path.'
'The particles will certainly increase the possibility of using nanoMOFs for drug delivery applications in the near future,' agrees Christian Serre, an expert in porous solids from the University of Versailles in France, 'and they'll add a new tool to the emerging domain of MOFs in biomedicine.'
Interesting? Spread the word using the 'tools' menu on the left.
Link to journal article
Heating and separation using nanomagnet-functionalized metal–organic frameworks
Martin R. Lohe, Kristina Gedrich, Thomas Freudenberg, Emanuel Kockrick, Til Dellmann and Stefan Kaskel, Chem. Commun., 2011, 47, 3075
Also of interest
Metal organic frameworks are molecular mops that have the potential to solve some of the world's most pressing environmental problems. Hayley Birch finds out more
23 February 2010
Metal-organic frameworks could be a new source of white light scientists discover
13 April 2010
US scientists have produced metal organic frameworks that release NO in a controlled manner for use in biomedical applications
Comment on this story at the Chemistry World blog
Read other posts and join in the discussion
External links will open in a new browser window