Computer-assisted drug design always looks like it’s just about to work,
says Derek Lowe, but the reality is complicated
Laboratory aromas conjure memories and emotions from elation to a sudden need to vomit, says Derek Lowe
In a chemistry lab, what you don’t know really can hurt you, says Derek Lowe
Chemistry is rarely the rate-limiting process in getting a drug to market, says Derek Lowe
You think it’s a long way to the back of your screening libraries? That’s peanuts to chemical space, says Derek Lowe
The rise of low-quality and predatory open access journals and conferences worries Derek Lowe
Fashion and progress combine to mean some reactions and reagents persist, while others fall by the wayside, says Derek Lowe
X-ray structures are not necessarily definitive, says Derek Lowe, especially when it comes to biomolecules
How strong is the correlation between company size and research productivity, asks Derek Lowe
Big company buyouts are more about immediate gains and rarely consider the impact on research, says Derek Lowe
It takes more than random stumbling to find new reactions, says Derek Lowe
New molecules with unpredictable biological activity deserve sensible amounts of respect, says Derek Lowe
Derek Lowe wonders what the most life-changing instrument for organic chemists is, and what might be missing from the toolbox
Derek Lowe thinks the Devil's R&D management schemes might be scarily familiar
Derek Lowe ponders whether anything is truly ‘undruggable’ if we look in the right places
Is Derek Lowe troubled by his failure to develop a compound that has made it to the pharmacy shelf?
Redesigning nature's catalysts is tantalising but tricky, says Derek Lowe
Not every reaction can be run in a bucket, says Derek Lowe, but there are limits to what should be classed as ‘useful’
Keeping up with the literature is impossible, says Derek Lowe.
Derek Lowe wonders whether we should mourn the decline of classic analytical techniques or embrace technological advances
Knowing a drug’s exact biochemistry has never been a prerequisite for approval, says Derek Lowe, and nor should it be
How long should scientists stay at the bench, asks Derek Lowe. How long is a piece of string?
A can-do attitude and some lateral thinking can save time and money when it comes to exotic apparatus, says Derek Lowe
Derek Lowe asks (with some trepidation): do drug companies need scientists at the top?
It’s more a research problem, than a commercial one, says Derek Lowe