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Now you’re talking my language

6 July 2016 In the Pipeline

Chemistry would be impossible without a hidden fluency that many of us don’t even realise we have, says Derek Lowe

Let's see that again

27 May 2016 In the Pipeline

Has chemistry evaded the reproducibility crises affecting other branches of science? Or is it just a question of scale, asks Derek Lowe

Valeant in defeat

9 May 2016 In the Pipeline

Derek Lowe looks at what can be learned from a drug company’s downfall

Throwing things over the fence

4 April 2016 In the Pipeline

Saying ‘That’s someone else’s problem’ is asking for trouble, says Derek Lowe

Drugs don’t grow on trees

15 March 2016 In the Pipeline

The trope of companies profiteering from academic discoveries doesn’t bear much scrutiny, says Derek Lowe

Pride comes before a fall

2 February 2016 In the Pipeline

In labs it’s important not to let familiarity breed complacency, says Derek Lowe

The sack race

23 December 2015 In the Pipeline

Looking to get fired? Derek Lowe offers some hot tips for a quick exit

Emerging from Babel

26 November 2015 In the Pipeline

Will English ever lose its place as the lingua franca of chemistry, asks Derek Lowe

What the market will bear?

30 September 2015 In the Pipeline

Martin Shkreli’s monopolising model poses some uncomfortable questions for the pharma industry, says Derek Lowe

Spice up your compounds

25 September 2015 In the Pipeline

An occasional foray into uncharted territory is the hot sauce of medicinal chemistry, says Derek Lowe

A risky business

28 August 2015 In the Pipeline

Graduate research is likely the most risky time of a chemist’s career, says Derek Lowe

A precision instrument?

30 July 2015 In the Pipeline

Chemists and biologists have different expectations when it comes to data, says Derek Lowe

Missing the target

23 June 2015 In the Pipeline

There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying

Magic molecule modifiers

29 May 2015 In the Pipeline

Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it

Missing mathematics?

29 April 2015 In the Pipeline

While you may not need differential calculus every day, mathematics is the basis of scientific thinking, says Derek Lowe

Analogues by catalogue

24 March 2015 In the Pipeline

Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe

Tantalising technology

20 February 2015 In the Pipeline

Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated

The smell of success

11 February 2015 In the Pipeline

Laboratory aromas conjure memories and emotions from elation to a sudden need to vomit, says Derek Lowe

Ignorance is no defence

14 January 2015 In the Pipeline

In a chemistry lab, what you don’t know really can hurt you, says Derek Lowe

Progress at the pace of the slowest

1 December 2014 In the Pipeline

Chemistry is rarely the rate-limiting process in getting a drug to market, says Derek Lowe

Chemical space is big. Really big.

28 October 2014 In the Pipeline

You think it’s a long way to the back of your screening libraries? That’s peanuts to chemical space, says Derek Lowe

Garbage in, garbage out

29 September 2014 In the Pipeline

The rise of low-quality and predatory open access journals and conferences worries Derek Lowe

Death of a reagent

22 August 2014 In the Pipeline

Fashion and progress combine to mean some reactions and reagents persist, while others fall by the wayside, says Derek Lowe

The crystal ball that can tell lies

29 July 2014 In the Pipeline

X-ray structures are not necessarily definitive, says Derek Lowe, especially when it comes to biomolecules

Too big to innovate?

25 June 2014 In the Pipeline

How strong is the correlation between company size and research productivity, asks Derek Lowe