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Gone to completion

26 November 2013 Totally Synthetic

After a 66-step journey, Paul Docherty ponders the future of total synthesis in his final column

Marcfortines B & C

5 November 2013 Totally Synthetic

Paul Docherty ponders a tasty cheeseboard as a source of synthetic inspiration


2 September 2013 Totally Synthetic

Sculpting a molecule from a larger whole is an unusual but effective strategy, says Paul Docherty

Melotenine A

30 July 2013 Totally Synthetic

Paul Docherty extols the virtues of chiral heteroatoms


27 June 2013 Totally Synthetic

A complex terpene gives Paul Docherty a headache


29 May 2013 Totally Synthetic

Labelling a molecule 'inaccessible to synthesis' is a red rag to a bull, says Paul Docherty

Kingianin A

1 May 2013 Totally Synthetic

Paul Docherty faces his fears of frontier molecular orbital theory


22 March 2013 Totally Synthetic

Polycyclic acutumine ties Paul Docherty up in knots

Lyconadin A

28 February 2013 Totally Synthetic

Paul Docherty tackles a serious repeat offender


24 January 2013 Totally Synthetic

A flexible natural product synthesis is the key to later drug development

Flueggine A

2 January 2013 Totally Synthetic

Some exotic heterocyclic chemistry catches Paul Docherty's eye

Pentalenolactone A methyl ester

27 November 2012 Totally Synthetic

Paul Docherty revises a reaction he never could quite remember

Epicoccin G

31 October 2012 Totally Synthetic

Paul Docherty gets to grips with some thiodiketopiperazines

Prostaglandin F2α

1 October 2012 Totally Synthetic

Paul Docherty comes face to face with an old adversary

Amphidinolide F

29 August 2012 Totally Synthetic

Symmetry in natural products isn’t always so apparent

Marinomycin A

27 July 2012 Totally Synthetic

Faced with the term ‘polymer’, most people would consider man-made materials


1 July 2012 Totally Synthetic

Cage-structured natural products are some of the most appealing targets for organic chemists

atrop-Abyssomicin C

31 May 2012 Totally Synthetic

Natural products frequently have hard to pronounce and even harder to spell names, often of little meaning.

Hopeahainol A and hopeanol

30 April 2012 Totally Synthetic

This month's synthesis looks somewhat familiar

Column: Totally Synthetic

26 April 2012 Totally Synthetic

Hopeanol and hopeahainol A

Indoxamycin B

31 March 2012 Totally Synthetic

It has always been the rearrangement reactions that did their best to elude my eye

Column: Totally Synthetic

28 March 2012 Totally Synthetic

Indoxamycin B

Column: Totally Synthetic

23 February 2012 Totally Synthetic

Scholarisine A

Column: Totally Synthetic

27 January 2012 Totally Synthetic

Asteriscunolide D

Column: Totally Synthetic

22 December 2011 Totally Synthetic

Dragmacidin D