Edward Jenner publishes his findings on cowpox and smallpox becoming the pioneer of vaccination. As a physician in a countryside practice Jenner was familiar with local observations that those who had caught cowpox were rendered immune to the fatal smallpox. Jenner found that it was possible to inject people with cowpox thus giving them immunity to smallpox. His discovery led to a fall in the death rate from smallpox of 3000 to 4000 per million in the eighteenth century to 90 per million after vaccination was enforced.