Issue 6, 2004

Facile protocol for the highly regioselective and stereodivergent synthesis of substituted bishomoallylic alcohols from esters

Abstract

Regio- and diastereoselective preparation of bishomoallylic alcohols was realized by a facile four-step protocol including α,α′-selective zinc-mediated bispropargylation of unactivated esters and stereoselective reduction of the resulting bishomopropargylic alcohols.

Graphical abstract: Facile protocol for the highly regioselective and stereodivergent synthesis of substituted bishomoallylic alcohols from esters

Article information

Article type
Communication
Submitted
03 Dec 2003
Accepted
26 Jan 2004
First published
17 Feb 2004

Chem. Commun., 2004, 692-693

Facile protocol for the highly regioselective and stereodivergent synthesis of substituted bishomoallylic alcohols from esters

M. Oestreich and F. Sempere-Culler, Chem. Commun., 2004, 692 DOI: 10.1039/B315758J

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