Issue 21, 2001
From the journal:

Chemical Communications

Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility

Gareth W. V. Cave,a   Colin L. Raston*b  and  Janet L. Scotta  

* Corresponding authors

a Centre for Green Chemistry, School of Chemistry, Monash University, Clayton, Melbourne, Victoria, Australia

b School of Chemistry, University of Leeds, Leeds, UK
E-mail: c.l.raston@chem.leeds.ac.uk

Abstract

A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Kröhnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.

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Article information

DOI
https://doi.org/10.1039/B106677N
Article type
Feature Article
Submitted
24 Jul 2001
Accepted
18 Sep 2001
First published
17 Oct 2001

Chem. Commun., 2001, 2159-2169

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Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility

G. W. V. Cave, C. L. Raston and J. L. Scott, Chem. Commun., 2001, 2159 DOI: 10.1039/B106677N

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