Issue 24, 2004
From the journal:

Chemical Communications

Hydroamination/Heck reaction sequence for a highly regioselective one-pot synthesis of indoles using 2-chloroaniline†

Lutz Ackermann,*a   Ludwig T. Kaspara  and  Christian J. Gschreia  

* Corresponding authors

a Department of Chemistry, Ludwig-Maximilians-Universität München, München, Germany
E-mail: lutz.ackermann@cup.uni-muenchen.de
Fax: +49 89 2180 77425
Tel: +49 89 2180 77675

Abstract

A one-pot indole synthesis consisting of a highly regioselective TiCl4-catalyzed hydroamination and a 5-endo Heck cyclization starting from 2-chloroaniline is described, using an in-situ generated, sterically hindered imidazol-2-ylidene palladium complex.

Graphical abstract: Hydroamination/Heck reaction sequence for a highly regioselective one-pot synthesis of indoles using 2-chloroaniline

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Article information

DOI
https://doi.org/10.1039/B411571F
Article type
Communication
Submitted
29 Jul 2004
Accepted
17 Sep 2004
First published
27 Oct 2004

Chem. Commun., 2004, 2824-2825

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Hydroamination/Heck reaction sequence for a highly regioselective one-pot synthesis of indoles using 2-chloroaniline

L. Ackermann, L. T. Kaspar and C. J. Gschrei, Chem. Commun., 2004, 2824 DOI: 10.1039/B411571F

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