Issue 14, 2005
From the journal:

Chemical Communications

X-Ray crystallographic signature of supramolecular triple helix formation from a water soluble synthetic tetrapeptide†

Apurba Kumar Das,a   Debasish Haldar,a   Raghurama P. Hegde,b   N. Shamala*b  and  Arindam Banerjee*a  

* Corresponding authors

a Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India
E-mail: bcab@mahendra.iacs.res.in
Fax: (+91) 33 2473-2805

b Department of Physics, Indian Institute of Science, Bangalore-560012, India
E-mail: shamala@physics.iisc.ernet.in
Fax: (+91) 080 23600683/(+91) 080 23602602

Abstract

Single crystal X-ray diffraction studies on the water soluble, synthetic tetrapeptide Tyr(1)–Aib(2)–Tyr(3)–Val(4) 1 with a non-coded amino acid residue (Aib: α-amino isobutyric acid) reveal that the peptide adopts an “S”-shaped molecular structure which self-assembles to form a supramolecular triple helix using various non-covalent interactions including water mediated hydrogen bonds in the solid state.

Graphical abstract: X-Ray crystallographic signature of supramolecular triple helix formation from a water soluble synthetic tetrapeptide

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Article information

DOI
https://doi.org/10.1039/B417726F
Article type
Communication
Submitted
25 Nov 2004
Accepted
03 Feb 2005
First published
16 Feb 2005

Chem. Commun., 2005, 1836-1838

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X-Ray crystallographic signature of supramolecular triple helix formation from a water soluble synthetic tetrapeptide

A. K. Das, D. Haldar, R. P. Hegde, N. Shamala and A. Banerjee, Chem. Commun., 2005, 1836 DOI: 10.1039/B417726F

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