Issue 21, 2007
From the journal:

Chemical Communications

Novel synthetic strategies for the preparation of prostacyclin and prostaglandin analogues – off the beaten track†

Neil A. Sheddan,*a   Michael Czybowskia  and  Johann Mulzer*a  

* Corresponding authors

a Institut für Organische Chemie, Währingerstrasse 38, A-1090 Wien, Austria
E-mail: neil.sheddan@univie.ac.at, johann.mulzer@univie.ac.at
Fax: +43 1 4277 52189
Tel: +43 1 4277 52190

Abstract

The recent increase in activity in the fields of neuroscience and life sciences has been mirrored by the design and synthesis of novel chemically and metabolically stable prostaglandin and prostacyclin analogues. Consequently, convenient and practical access to these important classes of compounds is greatly coveted. Various strategies for the preparation of prostacyclin, prostaglandin and isoprostane analogues are discussed, with particular focus on novel approaches developed in our own laboratories.

Graphical abstract: Novel synthetic strategies for the preparation of prostacyclin and prostaglandin analogues – off the beaten track

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Article information

DOI
https://doi.org/10.1039/B617693N
Article type
Feature Article
Submitted
04 Dec 2006
Accepted
12 Jan 2007
First published
14 Mar 2007

Chem. Commun., 2007, 2107-2120

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Novel synthetic strategies for the preparation of prostacyclin and prostaglandin analogues – off the beaten track

N. A. Sheddan, M. Czybowski and J. Mulzer, Chem. Commun., 2007, 2107 DOI: 10.1039/B617693N

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