Issue 29, 2008
From the journal:

Chemical Communications

A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a†‡

Stephen J. Roea  and  Robert A. Stockman§*a  

* Corresponding authors

a School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK

Abstract

Total syntheses of the potent neurotoxins, environmental hazards, and biochemical probes anatoxin-a and homoanatoxin have been achieved from a common intermediate using a combined two-directional synthesis–tandem reaction strategy which includes key advances in oxidative desymmetrisation, tandem Michael–intramolecular Mannich cyclisations and a new method for deprotection of N-tosyl anatoxin-a.

Graphical abstract: A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

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Article information

DOI
https://doi.org/10.1039/B804304C
Article type
Communication
Submitted
12 Mar 2008
Accepted
22 Apr 2008
First published
23 May 2008

Chem. Commun., 2008, 3432-3434

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A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

S. J. Roe and R. A. Stockman, Chem. Commun., 2008, 3432 DOI: 10.1039/B804304C

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