Issue 21, 2006
From the journal:

Organic & Biomolecular Chemistry

What I have learned by using chemical model systems to study biomolecular structure and interactions

James S. Nowick*a  

* Corresponding authors

a Department of Chemistry, University of California, Irvine, Irvine, USA
E-mail: jsnowick@uci.edu
Fax: +1 949-824-9920
Tel: +1 949-824-6091

Abstract

Chemical model systems provide valuable insights into biomolecular structure and interactions by allowing researchers to simplify, isolate, and manipulate aspects of the complex molecular machinery of living systems. This perspective describes my laboratory's design, synthesis, and study of chemical model systems that fold and self-assemble like proteins and elucidates the insights that have come from studying these systems. Many of these studies have focused on protein β-sheets, which exhibit fascinating intra- and intermolecular interactions and play important roles in protein folding, aggregation, and molecular recognition.

Graphical abstract: What I have learned by using chemical model systems to study biomolecular structure and interactions

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Article information

DOI
https://doi.org/10.1039/B608953B
Article type
Perspective
Submitted
23 Jun 2006
Accepted
04 Sep 2006
First published
18 Sep 2006

Org. Biomol. Chem., 2006,4, 3869-3885

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What I have learned by using chemical model systems to study biomolecular structure and interactions

J. S. Nowick, Org. Biomol. Chem., 2006, 4, 3869 DOI: 10.1039/B608953B

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