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Organic & Biomolecular Chemistry

An international journal for the quickest publication of high-quality research covering the breadth of synthetic, physical and biomolecular organic chemistry.



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Paper

Org. Biomol. Chem., 2007, 5, 1562 - 1568, DOI: 10.1039/b703033a


Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

Christopher D. Smith, Ian R. Baxendale, Geoffrey K. Tranmer, Marcus Baumann, Stephen C. Smith, Russell A. Lewthwaite and Steven V. Ley


The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.

Graphical abstract image for this article  (ID: b703033a)