Issue 3, 2007
From the journal:

Soft Matter

Vesicles as a model for controlled (de-)adhesion of cells: a thermodynamic approach†

Ana-Sunčana Smith*ab  and  Udo Seiferta  

* Corresponding authors

a II. Institut für Theoretische Physik, Universität Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart, Germany
E-mail: smith@theo2.physik.uni-stuttgart.de
Fax: +49 711 6856 4902
Tel: +49 711 6856 4926

b Institut für Theoretische Physik I, Universität Erlangen-Nürnberg, Staudtstraße 7, D-70550 Erlangen, Germany

Abstract

We review the specific adhesion between ligand-containing vesicles and receptor-functionalized substrates as an established model system used to study the cell recognition process and its control mechanisms. In order to provide better understanding of the underlying physics and to allow for quantitative exploitation of this system, we develop a simple theoretical framework that accounts for the equilibrium state of adhesion and successfully merges the macroscopic and microscopic aspects of the problem. Several mechanisms that are used to control adhesion or induce de-adhesion are studied on the same level of theory. Specifically, the repelling properties of adhesive molecules, the role of repelling molecules, the action of antagonists for a specific binder as well as the influence of an externally applied force are addressed independently within the same formalism.

Graphical abstract: Vesicles as a model for controlled (de-)adhesion of cells: a thermodynamic approach

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Article information

DOI
https://doi.org/10.1039/B611892E
Article type
Review Article
Submitted
17 Aug 2006
Accepted
24 Oct 2006
First published
08 Dec 2006

Soft Matter, 2007,3, 275-289

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Vesicles as a model for controlled (de-)adhesion of cells: a thermodynamic approach

A. Smith and U. Seifert, Soft Matter, 2007, 3, 275 DOI: 10.1039/B611892E

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