Paper

Dalton Trans., 2007, 5082 - 5090, DOI: 10.1039/b708283p

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Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

Olivia R. Allen, Andrew L. Gott, John A. Hartley, Janet M. Hartley, Richard J. Knox and Patrick C. McGowan

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A number of new ionic titanocene compounds have been isolated and characterised, which exhibit excellent cytotoxicity against different human tumour cell lines including a defined cisplatin resistant cell line. A range of biological assays have been carried out to determine levels of cytotoxicity and levels of DNA interstrand crosslinking.

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