Synthesis based on cyclohexadienes. Part 9. Total synthesis of (±)-seychellene
Abstract
A new strategy for the total synthesis of (±)-seychellene 1 is described. The key step is an intramolecular Michael addition involving a 6-exo cyclisation with a vinyl radical derived from the acetylenic compound 11, obtained from the bicyclo[2.2.2]octene adduct 5 to the tricyclic intermediates 14 and 15.