Ion Specific Hoffmeister Effects: Faraday Discussion 160

5 September 2012, Oxford, United Kingdom

The hydration of ions and the interactions of ions with (bio)molecules play a key role in many natural and technological processes. These effects are usually framed in terms of the lyotropic or Hofmeister series which traditionally orders cations and anions according to their ability to salt-out proteins. Since its formulation more than one hundred years ago, the lyotropic series has been invoked in myriad effects including the crystallization of proteins, enzyme activities, the swelling of tissues, salt solubilities, ion exchange, surface tension of electrolytes, and bubble coalescence. 

Although it is now clear that the Hofmeister series is intimately connected with ion hydration in homogeneous and heterogeneous environments and with ion pairing, the molecular origin of these effects has been poorly understood. Biochemists and physical chemists have been typically using the term Hofmeister series to put a label on ion specific behaviour in various environments, rather than to reach a molecular level understanding and, consequently, an ability to predict a particular effect of a specific salt ion.

AimsThis meeting aimed to respond to the emerging situation in which science has matured enough to be able to provide answers about the molecular nature of ion specific effects. It explored the most important issues in understanding the chemistry and biological effects of ions, with state of the art work being presented using advanced experimental and computational methods. 

Investigation of ion specific effects is truly interdisciplinary since it requires chemists, biochemists, and biophysicists to collaborate with each other, combining experimental and computational approaches. We invited researchers in these fields to take part in the Discussion and join the chosen speakers who are among the key scientists behind the recent renaissance of interest in ion specific effects.Themes 

Solvation of ions in the aqueous bulk and at interfaces
Ion-ion interactions in water
Interactions between ions and biomolecules (proteins, nucleic acids, membranes, etc.) in water.
Specific Hofmeister effects of ions and osmolytes on protein association, precipitation, folding/unfolding, and activity                   

Scientific Committee

Professor Pavel Jungwirth (Acad. Sci. Prague, Czech Republic) (Chair)
Professor Paul Cremer (Texas A&M University, USA)
Dr Jonathan Goodman (University of Cambridge, UK)
Professor Anthony Davis (University of Bristol, UK)
Professor Ruth Lynden-Bell (University of Cambridge, UK)
Professor Paul Madden (University of Oxford, UK)
Dr Bernd Winter (BESSY Berlin, Germany)


Sponsorship & supporting organisations
We would like to thank the British Biophysical Society for their co-sponsorship of this event.
Queen's Colleg Oxford

Queen's Colleg Oxford, High Street, Oxford, OX1 4AW, United Kingdom

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