Late Stage Functionalization for Synthesis and Medicines

5 December 2016 08:00-18:15, Oxford, United Kingdom

Late Stage Functionalization (LSF) holds the potential to revolutionize the logic of chemical synthesis and open new ways to prepare novel natural products and medicines. The introduction of important chemical groups for medicinal chemistry in the very last steps of the synthesis through LSF could also dramatically speed up the preparation of NCEs and have a major impact on drug discovery.  The availability of new powerful catalytic chemistries showing a high degree of functional group tolerance and that can be performed under mild conditions offer tremendous opportunities for chemists to access new molecules that cannot be made easily by conventional approaches.

Topics will cover hot and emerging areas in the field of late stage transformations (including C-H activation for total synthesis, oxidation, fluorination, alkylation, biocatalysts, transition metal catalysts, photoredox catalysts, late stage functionalization in medicinal chemistry, and late stage functionalization for PET chemistry).

Confirmed Speakers
The functionalization of C-H bonds
M Christina White, University of Illinois, Urbana-Champaign, USA

Late-stage fluorination
Tobias Ritter, Havard & Max Planck Institute, USA

Late stage fluorination: chemical, radiochemical and clinical advances
Véronique Gouverneur, University of Oxford, UK

C-H functionalization: a transformative technology for drug discovery
Shane Krska, Merck Rahway, USA

Cytochrome P450 monooxygenases in synthesis
Luet Wong, University of Oxford, UK

Ligand-accelerated C-H activation reactions: distance and geometry
Jin-Quan Yu, TSRI, USA

  • Six lectures delivered by leading scientists in the field
  • Poster session and award for best poster
  • Some posters selected for brief flash presentations
  • Round table discussion at the end of the symposium
  • A related trade exhibition
  • Drinks reception
  • Discounted rates are offered to RSC members, and some bursaries are available
Sponsorship & supporting organisations
University of Oxford

University of Oxford, Mathematical Institute, Andrew Wiles Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, United Kingdom

Organised by
RSC-BMCS and University of Oxford
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