Journal articles made easy: Natural product herbicide, thaxtomin A

Description

This article looks at developing a natural product herbicide, thaxtomin A. It will help you understand the research the journal article is based on, and how to read and understand journal articles. The research article was originally published in our Organic & Biomolecular Chemistry journal.

Type of Activity

:
working independently

Audience

:
TeacherStudent

Age Group

:
Undergraduate to Teacher
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Abbreviations used in text


Abbreviation

Name

Role

Links

DIBALH

Diisobutylaluminium hydride

Reducing agent for the conversion of the ester to a primary alcohol 

ChemSpider

DKP

2,5-diketopiperazine

Class of cyclic dipetides

ChemSpider

DOS

Diversity-Oriented Synthesis 

A strategy for quick access to molecule libraries with an emphasis on skeletal diversity

RSC journal article

Wiley journal article

HCl

Hydrochloric acid

Acid used as an aqueous source of H+ for the hydrolysis of the cyano group to a carboxylic acid 

ChemSpider

IBX

2-iodoxybenzoic acid 

Oxidizing agent used to convert the primary alcohol to an aldehyde

ChemSpider

KCN

Potassium cyanide

Nucleophile used to add an additional carbon atom

ChemSpider

KOH

Potassium hydroxide

Base used in the cylization of the acylic Ugi intermediate

ChemSpider

TA

Thaxtomin A

Natural bacterial herbicide/synthetic target

ChemSpider

TsCl

P-toluenesulfonyl chloride

Sulfonating reagent, which turns a free OH into a leaving group 

ChemSpider

ADDITIONAL INFORMATION

Journal articles made easy are journal articles from a range of Royal Society of Chemistry journals that have been re-written into a standard, accessible format. They contain links to ChemSpider entries, related journal articles, books and Learn Chemistry resources such as videos of techniques, and resources on theory and activities. They should facilitate students understanding of scientific journal articles and how to extract and interpret the information in them.