Substance:AMPA

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• Molecular formula: C₇H₁₀N₂O₄
• Molar mass: 186.165
• CAS Registry Number: Not available
• Appearance: Not available
• Melting point: Not available
• Boiling point: Not available
• Solubility: Soluble to 10 mM in water
• Safety sheet: Not available
• Spectra: Check on SDBS. Add Spectra (Help).

From Wikipedia

AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.

There are several types of glutamatergic ion channels in the central nervous system including AMPA, kainic acid and N-methyl-D-aspartic acid (NMDA) channels. In the synapse, these receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast excitatory postsynaptic potentials (EPSP). AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na⁺ and K⁺ and therefore have an equilibrium potential near 0 mV.

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Other names

3-(5-Methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)alanine (IUPAC Name); 2-Amino-3-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)propanoic acid; 2-ammonio-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoate; 3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)alanine; alpha-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid

References

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