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Substance:Dextromethorphan

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  • Main ChemSpider page
  • Molecular formula: C18H25NO
  • Molar mass: 271.397
  • CAS Registry Number: Not available
  • Appearance: Not available
  • Melting point: Not available
  • Boiling point: Not available
  • Solubility: Not available
  • Safety sheet: Not available
  • Spectra: Massbank MS (1, 2, 3, 4, 5), also check on SDBS. Add Spectra (Help).

From Wikipedia

Dextromethorphan (DXM or DM) is an antitussive (cough suppressant) drug. It is one of the active ingredients in many over-the-counter cold and cough medicines, including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetics such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.

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Other names

(14alpha)-3-Methoxy-17-methylmorphinan (IUPAC Name); (9a,13a,14a)-3-Methoxy-17-methylmorphinan; (9alpha,13alpha,14alpha)-17-methyl-3-(methyloxy)morphinan; (9alpha,13alpha,14alpha)-3-Methoxy-17-methylmorphinan; 3-Methoxy-17-methyl-9a,13a,14a-morphinan; Balminil DM; Benylin Pediatric Cough Suppressant; Cough-X; Creo-Terpin; Delsym Cough Formula; Demorphine; Dextrometorphan; Dexyromethorphan; Diabe-Tuss DM Syrup; Dormetan; Hold DM; Koffex DM; (9Alpha,13alpha,14alpha)-3-methoxy-17-methyl-morphinan; (9-Alpha,13-alpha,14-alpha)-3-methoxy-17-methyl-morphinan; Novahistex DM; Novahistine DM; Pertussin CS Children's Strength; Pertussin DM Extra Strength; Robitussin Maximum Strength Cough Suppressant; Robitussin Pediatric; Robitussin Pediatric Cough Suppressant; Sucrets 4 Hour Cough Suppressant; Triaminic DM Long Lasting for Children; Trocal; Vicks 44 Cough Relief

References

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