Issue 5, 1986
From the journal:

Journal of the Chemical Society, Chemical Communications

Retrosynthetic and synthetic chemistry on amphotericin B. Synthesis of C(1)–C(20) and C(21)–C(38) fragments and construction of the 38-membered macrocycle

K. C. Nicolaou,   T. K. Chakraborty,   R. A. Daines  and  N. S. Simpkins  

Abstract

For the first time, amphotericin B (I) has been successfully derivatized and degraded to intermediates that have been converted into compounds (II)[C(1)–C(20) fragment] and (III)[C(21)–C(38) fragment], projected as major key intermediates for a total synthesis; methods have been developed for the coupling of fragments (II) and (III) to give the ketophosphonate–aldehyde (28) and for the cyclization of this preculrsor to the 38-membered macrocyclic heptaenone (29) in 70–80% yield.

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Article information

DOI
https://doi.org/10.1039/C39860000413
Article type
Paper

J. Chem. Soc., Chem. Commun., 1986, 413-416

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Retrosynthetic and synthetic chemistry on amphotericin B. Synthesis of C(1)–C(20) and C(21)–C(38) fragments and construction of the 38-membered macrocycle

K. C. Nicolaou, T. K. Chakraborty, R. A. Daines and N. S. Simpkins, J. Chem. Soc., Chem. Commun., 1986, 413 DOI: 10.1039/C39860000413

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