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Journal of the Chemical Society, Chemical Communications


Journal of the Chemical Society, Chemical Communications was published between 1972 - 1995.

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Paper

J. Chem. Soc., Chem. Commun., 1988, 274 - 276, DOI: 10.1039/C39880000274


Novel -lactamase inhibitory and antibacterial 6-spiro-epoxypenicillins

Barrie W. Bycroft, Richard E. Shute and Michael J. Begley


A series of novel 6-spiro-epoxypenicillins prepared by the reaction of diazopenicillanates with oxalyl halides followed by various nucleophiles is reported; these compounds exhibit notable -lactamase inhibitory and antibacterial properties dependent on the substituents and stereochemistry of the epoxide.