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Urgent high quality communications from across the chemical sciences.
Contents list for Chemical Communications, issue 8, 2010
Front cover
Chem. Commun., 2010, 46, 1173
DOI: 10.1039/c001755h
Inside front cover
Chem. Commun., 2010, 46, 1174
DOI: 10.1039/c001757b
Contents
Chem. Commun., 2010, 46, 1175
DOI: 10.1039/c001759k
Feature Article
Protein–protein coupling and its application to functional red cell substitutes
Ronald Kluger, Jonathan S. Foot and Adelle A. Vandersteen,
Chem. Commun., 2010, 46, 1194
DOI: 10.1039/b922694j
Hemoglobin tetramers (
2
2) react with site-directed ester reagents or by click-coupling to form cross-linked bis-tetramers, which are potential red blood cell substitutes.
Communications
Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3+
Sarah L. Binkley, Christopher J. Ziegler, Richard S. Herrick and Roger S. Rowlett,
Chem. Commun., 2010, 46, 1203
DOI: 10.1039/b923688k
The reaction of Re(CO)3(H2O)3+ with hen egg lysozyme in aqueous solution results in a single covalent adduct; single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to His15 in two significantly populated rotamer conformations.
A new system for synthesis of high quality nonpolar GaN thin films
Guoqiang Li, Shao-Ju Shih and Zhengyi Fu,
Chem. Commun., 2010, 46, 1206
DOI: 10.1039/b919722b
High quality nonpolar m-plane GaN films were successfully grown on LiGaO2 (100) substrates for the first time. This m-plane GaN/LiGaO2 (100) system opens a new approach for realizing highly-efficient nitride devices.
pH-triggered switchable Mg2+-dependent DNAzymes
Johann Elbaz, Simcha Shimron and Itamar Willner,
Chem. Commun., 2010, 46, 1209
DOI: 10.1039/b919417g
The biocatalytic functions of the Mg2+-DNAzyme are switched 
ON
and OFF by the pH-controlled assembly or disassembly of the DNAzyme subunits by means of an i-motif regulating unit.
Platinum(II) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity
Zuqin Xue, Miaoxin Lin, Jianhui Zhu, Junfeng Zhang, Yizhi Li and Zijian Guo,
Chem. Commun., 2010, 46, 1212
DOI: 10.1039/b922222g
Platinum(II) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show remarkable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.
Confused ionic liquid ions—a liquification and dosage strategy for pharmaceutically active salts
Katharina Bica and Robin D. Rogers,
Chem. Commun., 2010, 46, 1215
DOI: 10.1039/b925147b
The liquid and compositional ranges of ionic liquids, specifically pharmaceutically active ionic liquids, can be expanded by simple mixing with a solid acid or base to form oligomeric ions.
Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction
Arun K. Ghosh and Jorden Kass,
Chem. Commun., 2010, 46, 1218
DOI: 10.1039/b924807b
We have developed a practical synthesis of unique nucleoside derivatives via TiCl4 promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation.
DNA–polyfluorophore excimers as sensitive reporters for esterases and lipases
Nan Dai, Yin Nah Teo and Eric T. Kool,
Chem. Commun., 2010, 46, 1221
DOI: 10.1039/b926338a
Esterase/lipase sensors built with DNA-scaffolded polyfluorophores displayed high quenching efficiency and yielded large signal increases in vitro and in intact human cells.
A redox-switchable [2]rotaxane in a liquid-crystalline state
Takuma Yasuda, Kana Tanabe, Toru Tsuji, Karla K. Coti, Ivan Aprahamian, J. Fraser Stoddart and Takashi Kato,
Chem. Commun., 2010, 46, 1224
DOI: 10.1039/b922088g
Redox-driven mechanical movement has been achieved for a bistable [2]rotaxane in the self-assembled liquid-crystalline phase.
The first example of metallocene-like coordination mode of THBQ4-: A mixed-valence heptanucler palladium complex [Pd7(THBQ)2(tben)6](PF6)4
Eiji Asato, Ayano Kyan, Tomokura Madanbashi, Toshihide Tamura, Makoto Tadokoro and Motohiro Mizuno,
Chem. Commun., 2010, 46, 1227
DOI: 10.1039/b919854g
An unprecedented coordination mode of THBQ4- was newly discovered in a heptanuclear Pd complex, in which Pd(0) was sandwiched through 
-bonding by two THBQ4- ligands.
Spin crossover characteristics of nanofibrous FeII-1,2,4-triazole complexes in liquid crystals
Keita Kuroiwa, Hirotsugu Kikuchi and Nobuo Kimizuka,
Chem. Commun., 2010, 46, 1229
DOI: 10.1039/b920631k
A lipophilic Fe(II) triazole complex formed nanofibrous assemblies in liquid crystals, which caused physical gelation. Thermal spin crossover characteristics are considerably modulated through interactions with liquid crystals.
Activation of H2 by a highly distorted Rh II complex with a new C3-symmetric tripodal tetraphosphine ligand
Jeroen Wassenaar, Bas de Bruin, Maxime A. Siegler, Anthony L. Spek, Joost N. H. Reek and Jarl Ivar van der Vlugt,
Chem. Commun., 2010, 46, 1232
DOI: 10.1039/b917632b
The synthesis and reactivity of a RhI-complex featuring a novel tripodal ligand are detailed. Oxidation leads to the isolation of a stable RhII derivative that can activate dihydrogen in an unprecedented manner, ultimately yielding the stable RhIII-hydride analogue.
Dimeric nanocapsule induces conformational change
Andrew K. Maerz, Haunani M. Thomas, Nicholas P. Power, Carol A. Deakyne and Jerry L. Atwood,
Chem. Commun., 2010, 46, 1235
DOI: 10.1039/b921911k
A chair-to-cone structural rearrangement induced by the addition of a pentacoordinate zinc(II) complex.
From glycerol to allyl alcohol: iron oxide catalyzed dehydration and consecutive hydrogen transfer
Yong Liu, Harun Tüysüz, Chun-Jiang Jia, Manfred Schwickardi, Roberto Rinaldi, An-Hui Lu, Wolfgang Schmidt and Ferdi Schüth,
Chem. Commun., 2010, 46, 1238
DOI: 10.1039/b921648k
A process for the conversion of glycerol to allyl alcohol over an iron oxide catalyst has been discovered, and a dehydration and consecutive hydrogen transfer mechanism has been proposed.
Enzymatic activation of a matrix metalloproteinase inhibitor
Jody L. Major Jourden and Seth M. Cohen,
Chem. Commun., 2010, 46, 1241
DOI: 10.1039/b923302d
Compounds containing glucoside-modified metal-binding groups can be activated with -glucosidase to generate potent matrix metalloproteinase (MMP) inhibitors. The enzyme completely and cleanly cleaves the glucose unit, liberating the metal-binding portion of the inhibitor, and leading to inhibition of the zinc-dependent MMP.
Highly enantioselective hydroformylation of dihydrofurans catalyzed by hybrid phosphine–phosphonite rhodium complexes
Samir H. Chikkali, Rosalba Bellini, Guillaume Berthon-Gelloz, Jarl Ivar van der Vlugt, Bas de Bruin and Joost N. H. Reek,
Chem. Commun., 2010, 46, 1244
DOI: 10.1039/b924046b
Unprecedented regio- and enantioselectivities (>91%) are reported for the Rh-catalyzed asymmetric hydroformylation of 2,3- and 2,5-dihydrofuran using tunable hybrid phosphine–phosphonite ligands.
Programmed assembly of organic radicals on DNA
Kensuke Maekawa, Shigeaki Nakazawa, Hiroshi Atsumi, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui and Kazuhiko Nakatani,
Chem. Commun., 2010, 46, 1247
DOI: 10.1039/b913061f
Nitronyl nitroxide radicals linked with naphyridine carbamate dimer are noncovalently assembled into DNA duplexes containing a CGG/CGG triad as an addressable position, leading to the remarkable changes of line shapes in ESR spectra.
Highly enantioselective -chlorination of cyclic -ketoesters catalyzed by N,N
-Dioxide using NCS as the chlorine source
Yunfei Cai, Wentao Wang, Ke Shen, Jun Wang, Xiaolei Hu, Lili Lin, Xiaohua Liu and Xiaoming Feng,
Chem. Commun., 2010, 46, 1250
DOI: 10.1039/b922769e
A simple and highly efficient N,N-dioxide organocatalyst system was developed for asymmetric -chlorination of cyclic -ketoesters using easily available NCS as the chlorine source to provide a series of optically active -chloro--ketoesters in excellent yields with 90–98% ee.
Serendipity strikes again—efficient preparation of lithium tetramethylcuprate(III) via rapid injection NMR
Erika R. Bartholomew, Steven H. Bertz, Stephen K. Cope, Michael D. Murphy, Craig A. Ogle and Andy A. Thomas,
Chem. Commun., 2010, 46, 1253
DOI: 10.1039/b924000d
Lithium tetramethylcuprate(III), the CuIII analog of the Gilman reagent, is efficiently prepared via addition of 2,3-dichloropropene to a mixture of 1 equiv. of halo-Gilman reagent, e.g., Me2CuLi·LiCl, and 2 equiv. of MeLi at -100 °C.
Organocuprate(III) chemistry: synthesis and reactivity of amido, cyano, phosphido and thiolato ate complexes of copper(III)
Steven H. Bertz, Michael D. Murphy, Craig A. Ogle and Andy A. Thomas,
Chem. Commun., 2010, 46, 1255
DOI: 10.1039/b921412g
Electrophilic and nucleophilic reagents can be used to induce transformations in organocopper(III) complexes, leading to surprisingly rich chemistry on the CuIII plateau, studied by rapid injection NMR.
Silver nanoclusters as fluorescent probes for selective and sensitive detection of copper ions
Guo-Yu Lan, Chih-Ching Huang and Huan-Tsung Chang,
Chem. Commun., 2010, 46, 1257
DOI: 10.1039/b920783j
Fluorescent DNA–Ag NCs are demonstrated as label-free, and turn-on fluorescence probes for Cu2+ sensors—this novel fluorescent probe was used to determine Cu2+ ions in Montana soil and pond water.
Aldehyde allylation with allylboronates providing -addition products
Sh
Kobayashi, Toshimitsu Endo, Uwe Schneider and Masaharu Ueno,
Chem. Commun., 2010, 46, 1260
DOI: 10.1039/b924527h
Enhanced HTML article available
Zn(OH)2-catalyzed allylation reactions of allylboronates with aldehydes proceeded smoothly in aqueous media. When -substituted allylboronates were employed, the -addition products were obtained exclusively, and syn-adducts were formed selectively in most cases.
Synthesis of a new fluorescent conjugated polymer microsphere for chemical sensing in aqueous media
A. Salinas-Castillo, M. Camprubí-Robles and R. Mallavia,
Chem. Commun., 2010, 46, 1263
DOI: 10.1039/b918784g
A novel conjugated polymer microsphere of high value for fluorescent sensing in aqueous media has been synthesized. New conjugated polymers were functionalized in the side chain with imidazole moieties (recognition element) and a terminal double bond (covalently linked to an organic matrix) through a post-functionalization strategy.
A novel dipeptidomimetic containing a cyclic threonine
Frank Sicherl, Tommaso Cupido and Fernando Albericio,
Chem. Commun., 2010, 46, 1266
DOI: 10.1039/b915220b
An efficient and simple two-step procedure for the formation of hydroxy-Freidinger lactams is presented.
Ag-containing all-carbon 1,3-dipoles: generation and formal cycloaddition for furo[3,2-b]-/
-lactams
Zhiguo Zhang, Qian Zhang, Zhikun Ni and Qun Liu,
Chem. Commun., 2010, 46, 1269
DOI: 10.1039/b917856b
A new strategy for highly diastereoselective synthesis of furo[3,2-b]--lactams and furo[3,2-b]--lactams via a novel Ag(I)-mediated intramolecular 1,3-dipolar cycloaddition of acyclic precursors, oxo-N-propargylamides, is developed.
An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne
Christian Spiteri, Pallavi Sharma, Fengzhi Zhang, Simon J. F. Macdonald, Steve Keeling and John E. Moses,
Chem. Commun., 2010, 46, 1272
DOI: 10.1039/b922489k Enhanced HTML article available
In less than 30 s, in situ generated nitrile oxides 
click
together with in situ generated benzyne to give 1,2-benzisoxazoles, in good to excellent yields.
Asymmetric organocatalytic formal double-arylation of azomethines for the synthesis of highly enantiomerically enriched isoindolines
Chao Wang, Xiao-Hua Chen, Shi-Ming Zhou and Liu-Zhu Gong,
Chem. Commun., 2010, 46, 1275
DOI: 10.1039/b917246g
Isoindoline derivatives with high enantiomeric purity have been accessed by formal double arylation of azomethines.
Controlled mineralization by extracellular matrix: monodisperse, colloidally stable calcium phosphate-hyaluronan hybrid nanospheres
Zhenhua Chen, Huihui Zhou, Xiaoliang Wang, Lin Sang, Caihong Wang, Jianfeng Ma and Xudong Li,
Chem. Commun., 2010, 46, 1278
DOI: 10.1039/b918835e
Uniform, monodisperse calcium phosphate nanospheres (40 nm) were prepared using a simple co-precipitation method via the segregation crystallization imposed by hyaluronan molecules. The nanospheres exhibit excellent colloidal/storage stability in water.
Mukaiyama aldol addition to -chloro-substituted aldehydes. Origin of the unexpected syn selectivity
Tessie Borg, Jakob Danielsson and Peter Somfai,
Chem. Commun., 2010, 46, 1281
DOI: 10.1039/b922954j Enhanced HTML article available
The addition of sterically demanding enolsilanes to -chloro aldehydes results unexpectedly in preferential formation of the anti-Cornforth product (1,2-syn), with complete reversal of the diastereoselectivity compared with the analogous boron enolate addition. A stereoinduction model explaining the observed inconsistency is proposed.
Electrochemical hydroxylation of organoboron compounds
Kohei Hosoi, Yu Kuriyama, Shinsuke Inagi and Toshio Fuchigami,
Chem. Commun., 2010, 46, 1284
DOI: 10.1039/b914093j
Cathodic hydroxylation of organoboron compounds was successfully performed under an oxygen atmosphere, producing the corresponding phenol derivatives with high selectivity and efficiency.
Mineralization of organic acids in aqueous suspensions of gold nanoparticles supported on cerium(IV) oxide powder under visible light irradiation
Hiroshi Kominami, Atsuhiro Tanaka and Keiji Hashimoto,
Chem. Commun., 2010, 46, 1287
DOI: 10.1039/b919598j
Gold nanoparticles supported on cerium(IV) oxide powder exhibited a higher level of activity than other Au-supporting samples under irradiation of visible light (> ca. 520 nm).
A catalytic nanostructured cobalt oxide electrode enables positive potential operation for the cathodic electrogenerated chemiluminescence of Ru(bpy)32+ with dramatically enhanced intensity
Weiling Guo, Yifeng E, li Gao, Louzhen Fan and Shihe Yang,
Chem. Commun., 2010, 46, 1290
DOI: 10.1039/b919370g
A novel cathodic ECL scheme is featured by a positive switch-on potential at +0.6 V (vs. Ag/AgCl) and a strong light emission clearly visible to the naked eye together with high stability, reproducibility and cyclability.
Host–guest interactions in azafullerene (C59N)-single-wall carbon nanotube (SWCNT) peapod hybrid structures
Yoko Iizumi, Toshiya Okazaki, Zheng Liu, Kazu Suenaga, Takeshi Nakanishi, Sumio Iijima, Georgios Rotas and Nikos Tagmatarchis,
Chem. Commun., 2010, 46, 1293
DOI: 10.1039/b917619e
The effect of azafullerene encapsulation on the electronic states of single-wall carbon nanotubes (SWCNTs) is investigated.
Metallo-supramolecular diblock copolymers based on heteroleptic cobalt(III) and nickel(II) bis-terpyridine complexes
Clément Mugemana, Pierre Guillet, Stephanie Hoeppener, Ulrich S. Schubert, Charles-André Fustin and Jean-François Gohy,
Chem. Commun., 2010, 46, 1296
DOI: 10.1039/b923270b
Metallo-supramolecular amphiphilic block copolymers containing a reversible cobalt(III) or nickel(II) heteroleptic bis-terpyridine complex at the junction between a polystyrene and a poly(ethylene oxide) block have been prepared.
Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH
Arivazhagan Rajendran, Shu-ichi Nakano and Naoki Sugimoto,
Chem. Commun., 2010, 46, 1299
DOI: 10.1039/b922050j
Unstructured triplet repeat DNAs adopt the i-motif structure at neutral pH by molecular crowding. At this condition, the pKa of N3 of cytosine was raised. Crowding is known to accelerate the formation of the multi-stranded i-motif, while the triplet repeats adopt single-strand structure.
Ammonia oxide makes up some 20% of an aqueous solution of hydroxylamine
Anthony J. Kirby, John E. Davies, David J. Fox, David R. W. Hodgson, Andrés E. Goeta, Marcelo F. Lima, Jacks P. Priebe, J. Arturo Santaballa and Faruk Nome,
Chem. Commun., 2010, 46, 1302
DOI: 10.1039/b923742a
Three independent estimates of pKaO indicate that aqueous solutions of hydroxylamine contain some 20% of ammonia oxide, NH3+–O-.
Mn based olivine electrode material with high power and energy
Jongsoon Kim, Dong-Hwa Seo, Sung-Wook Kim, Young-Uk Park and Kisuk Kang,
Chem. Commun., 2010, 46, 1305
DOI: 10.1039/b922133f
We report an Mn based olivine elecrode material with high power and energy. Easier and more frequent nucleation by Fe and Co in Mn-based olivines significantly enhanced the rate capability as evidenced by the electrochemical results.
A new kind CO2/CH4 separation material: open ended nitrogen doped carbon nanotubes formed by direct pyrolysis of metal organic frameworks
Yongming Shen and Junfeng Bai,
Chem. Commun., 2010, 46, 1308
DOI: 10.1039/b913820j
Unprecedented open ended nitrogen doped carbon nanotubes prepared by direct pyrolysis of [Co(HTTG)(H2O)2]n show among the largest surface area of multiwalled nanotubes and high CO2/CH4 adsorption selectivity which increases with increasing of nitrogen content.
Fluorescence turn-on detection of Cu2+ in water samples and living cells based on the unprecedented copper-mediated dihydrorosamine oxidation reaction
Weiying Lin, Lingliang Long, Bingbing Chen, Wen Tan and Wensha Gao,
Chem. Commun., 2010, 46, 1311
DOI: 10.1039/b919531a
A new fluorescence turn-on probe for Cu2+ based on the unprecedented copper-mediated dihydrorosamine oxidation reaction has been constructed and employed in the detection of Cu2+ in water and cells.
Facile and rapid manipulation of DNA surface density on gold nanoparticles using mononucleotide-mediated conjugation
Wenting Zhao and I-Ming Hsing,
Chem. Commun., 2010, 46, 1314
DOI: 10.1039/b920696e
The number of DNA molecules attached per gold nanoparticle was tuned from a few to tens in less than an hour.
Controlled drug release from porous materials by plasma polymer deposition
Spomenka Simovic, Dusan Losic and Krasimir Vasilev,
Chem. Commun., 2010, 46, 1317
DOI: 10.1039/b919840g
We present a novel approach for control of drug release from mesoporous materials. The method is based on deposition of a plasma polymer layer with controlled thickness which reduces a pore diameter and, hence, defines the rate of drug release.
Ultramicropore formation in PAN/camphor-based carbon nanofiber paper
Eun Ju Ra, Tae Hyung Kim, Woo Jong Yu, Kay Hyeok An and Young Hee Lee,
Chem. Commun., 2010, 46, 1320
DOI: 10.1039/b919055d
A new chemical route for forming ultramicropores in carbon nanofibers by using a pore former, camphor, in electrospun polyacrilnitrile nanofibers is reported. The total specific surface area was 886 m2 g-1, which is similar to the activated carbon nanofibers in CO2 and steam activation.
Highly enhanced electrochemiluminescence of novel gold/silica/CdSe-CdS nanostructures for ultrasensitive immunoassay of protein tumor marker
Gui-Fen Jie, Ping Liu and Shu-Sheng Zhang,
Chem. Commun., 2010, 46, 1323
DOI: 10.1039/b919186k
We have reported the first observation of highly enhanced electrochemiluminescence (ECL) from a novel hybrid gold/silica/CdSe-CdS quantum-dot nanostructure, and have developed an ultrasensitive ECL immunosensor for the detection of a protein tumor marker, carcinoembryonic antigen (CEA).
Dextran based pH-activated near-infrared fluorescence nanoprobe imaging the acidic compartments in cancer cells
Cong Li, Kai Li, Huihui Yan, Guanghui Li, Jinsong Xia and Xunbin Wei,
Chem. Commun., 2010, 46, 1326
DOI: 10.1039/b917368d
A biodegradable nanoprobe NP1 was synthesized and demonstrated the pH activated near-infrared (NIR) fluorescence in the acidic compartments of human glioblastoma cancer cells.
An unusual case of symmetry-preserving isomerism
Daofeng Sun, Shengqian Ma, Jason M. Simmons, Jian-Rong Li, Daqiang Yuan and Hong-Cai Zhou,
Chem. Commun., 2010, 46, 1329
DOI: 10.1039/b920995f
Two symmetry-preserving, supramolecular stereo-isomers of the NbO-type structure have been discovered: the phase and the phase. Gas sorption studies revealed that the phase possesses higher gas adsorption capacities than the phase.
End-to-end assembly of gold nanorods by means of oligonucleotide–mercury(II) molecular recognition
Yi Wang, Yuan Fang Li, Jian Wang, You Sang and Cheng Zhi Huang,
Chem. Commun., 2010, 46, 1332
DOI: 10.1039/b921464j
We report a novel, simple, highly selective and versatile approach for the end-to-end assembly of gold nanorods (GNRs) by means of the specific molecular recognition between thymine-rich (T-rich) oligonucleotides and mercury(II).
High performance organic photosensitizers for dye-sensitized solar cells
Hunbae Im, Sukwon Kim, Chanmoo Park, Seok-Hoon Jang, Chang-Ju Kim, Kyungkon Kim, Nam-Gyu Park and Chulhee Kim,
Chem. Commun., 2010, 46, 1335
DOI: 10.1039/b917065k
We have synthesized high performance organic photosensitizers containing alkoxy-substituted oligophenylenevinylene linkers with electron donor–acceptor units for DSSCs; one of which showed an overall solar-to-energy conversion efficiency of 9.67% at AM 1.5 illumination.
On the tuning of electric conductance of extended metal atom chains via axial ligands for [Ru3(
3-dpa)4(X)2]0/+ (X = NCS-, CN-)
Kai-Neng Shih, Min-Jie Huang, Hao-Cheng Lu, Ming-Dung Fu, Ching-Kuo Kuo, Gin-Chen Huang, Gene-Hsiang Lee, Chun-hsien Chen and Shie-Ming Peng,
Chem. Commun., 2010, 46, 1338
DOI: 10.1039/b916677g
The influence of the axial ligand on the metal-metal interactions of [Ru3(
3-dpa)4X2]0/+ is manifested by their electric conductance under electrochemical control.
Macroscopic evidence of strong cation– interactions in a synthetic polymer system
Ruomiao Wang and Tao Xie,
Chem. Commun., 2010, 46, 1341
DOI: 10.1039/b916204f
Evidence of strong cation– interactions is presented via macroscopic direct adhesion between synthetic polymers.
Emulsion-assisted synthesis of monodisperse binary metal nanoparticles
Zhen Yin, Ding Ma and Xinhe Bao,
Chem. Commun., 2010, 46, 1344
DOI: 10.1039/b920169f
An easy-to-scale-up multiphase emulsion-assisted synthetic strategy based on a ternary metal precursor/surfactant/ethylene glycol system has been established to prepare monodispersed bimetallic nanoparticles with designated size and composition; the nanoparticles thus prepared are easily separable from the reaction mixture.
Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling
Fu-An Kang, James C . Lanter, Chaozhong Cai, Zhihua Sui and William V. Murray,
Chem. Commun., 2010, 46, 1347
DOI: 10.1039/b917777a
The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C–H/C–OH bond activations with direct C(sp2)–C(sp) bond formation, which is in line with ideal synthesis using readily available materials.
Back matter
Chem. Commun., 2010, 46, 1350
DOI: 10.1039/c001762k
Back cover
Chem. Commun., 2010, 46, 1351
DOI: 10.1039/c001760b
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