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Chem. Commun., 2008, 4261 - 4263, DOI: 10.1039/b810978h

Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

Craig P. Montgomery, Elizabeth J. New, David Parker and Robert D. Peacock

The helicity of the (SSS)- enantiomer of a terbium and europium(III) complex is inverted on reversible binding to drug site II of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)- complexes, thereby defining a unique chiroptical probe of albumin binding.

Graphical abstract image for this article (ID: b810978h)