Issue 27, 2010

Method for regio-, chemo- and stereoselective deuteriumlabeling of sugars based on ruthenium-catalyzed C–H bond activation

Abstract

An efficient and facile deuterium labeling of sugars has been achieved in a completely regio-, chemo- and stereoselective manner using the Ru/C–H2–D2O combination via C–H bond activation assisted by the coordination of Ru to the oxygen atom of the sugar-hydroxyl groups.

Graphical abstract: Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C–H bond activation

Supplementary files

Article information

Article type
Communication
Submitted
30 Apr 2010
Accepted
27 May 2010
First published
14 Jun 2010

Chem. Commun., 2010,46, 4977-4979

Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C–H bond activation

Y. Fujiwara, H. Iwata, Y. Sawama, Y. Monguchi and H. Sajiki, Chem. Commun., 2010, 46, 4977 DOI: 10.1039/C0CC01197E

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