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Chem. Commun., 2001, 1792 - 1793, DOI: 10.1039/b105293b

New and easy route to primary cyclopropylamines from nitriles

Philippe Bertus and Jan Szymoniak

Starting from readily available substrates, we have developed a new synthesis of primary cyclopropylamines. The reaction involves a cooperative Ti(II)- and Lewis acid-mediated coupling of alkanenitriles with Grignard reagents.