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Feature Article

Chem. Commun., 2004, 253 - 265, DOI: 10.1039/b309910e

The tethered Biginelli condensation in natural product synthesis

Zachary D. Aron and Larry E. Overman

This review describes the development of the tethered Biginelli condensation and its application to the total synthesis of structurally complex, bioactive guanidine alkaloids.

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