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Chem. Commun., 2004, 2824 - 2825, DOI: 10.1039/b411571f

Hydroamination/Heck reaction sequence for a highly regioselective one-pot synthesis of indoles using 2-chloroaniline

Lutz Ackermann, Ludwig T. Kaspar and Christian J. Gschrei

A one-pot indole synthesis consisting of a highly regioselective TiCl4-catalyzed hydroamination and a 5-endo Heck cyclization starting from 2-chloroaniline is described, using an in-situ generated, sterically hindered imidazol-2-ylidene palladium complex.

Graphical abstract image for this article (ID: b411571f)